Partial heart xenotransplantation: A research protocol in non-human primates.

Autor: Rajab TK; Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA., Goerlich CE; Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA., Forbess JM; Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA., Griffith BP; Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA., Mohiuddin MM; Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Jazyk: angličtina
Zdroj: Artificial organs [Artif Organs] 2023 Aug; Vol. 47 (8), pp. 1262-1266. Date of Electronic Publication: 2023 Apr 21.
DOI: 10.1111/aor.14546
Abstrakt: Partial heart transplantation is a new type of transplant that delivers growing heart valve replacements for babies. Partial heart transplantation differs from orthotopic heart transplantation because only the part of the heart containing the heart valve is transplanted. It also differs from homograft valve replacement because viability of the graft is preserved by tissue matching, minimizing donor ischemia times, and recipient immunosuppression. This preserves partial heart transplant viability and allows the grafts to fulfill biological functions such as growth and self-repair. These advantages over conventional heart valve prostheses are balanced by similar disadvantages as other organ transplants, most importantly limitations in donor graft availability. Prodigious progress in xenotransplantation promises to solve this problem by providing an unlimited source of donor grafts. In order to study partial heart xenotransplantation, a suitable large animal model is important. Here we describe our research protocol for partial heart xenotransplantation in nonhuman primates.
(© 2023 International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC.)
Databáze: MEDLINE
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