Loneliness during the Covid-19 pandemic in Germany: Impact of social factors and polygenic risk scores on interpersonal differences in loneliness and mental health.

Autor: von Werthern NM; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Ahrens KF; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Neumann RJ; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Kollmann B; Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany.; Leibniz Institute for Resilience Research (LIR), Mainz, Germany., Kranz TM; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Lieb K; Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany.; Leibniz Institute for Resilience Research (LIR), Mainz, Germany., Tüscher O; Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany.; Leibniz Institute for Resilience Research (LIR), Mainz, Germany., Reif A; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Fiebach CJ; Department of Psychology, Goethe University Frankfurt, Frankfurt, Germany.; Brain Imaging Center, Goethe University Frankfurt, Frankfurt, Germany., Plichta MM; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.
Jazyk: angličtina
Zdroj: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2023 Nov; Vol. 24 (9), pp. 838-848. Date of Electronic Publication: 2023 Jul 31.
DOI: 10.1080/15622975.2023.2226201
Abstrakt: Objectives: The outbreak of Covid-19 negatively affected mental health and increased loneliness. The subjective feeling of loneliness is influenced by genetic and social factors and has a negative impact on mental health.
Methods: From March 2020 to June 2021 loneliness was investigated in N = 517 individuals using monthly acquired questionnaire data and Latent Growth Curve Analysis. Associations of social factors and polygenic risk scores (PRSs, n = 361) with class membership were investigated.
Results: Three classes ("average", 40%; "not lonely", 38%; "elevated loneliness", 22%) were identified, that differ significantly regarding loneliness, mental dysfunction, and response to the lockdown phases. Individuals with a high PRS for neuroticism are more likely to belong to the "elevated loneliness" class, living with another person is a protective factor.
Conclusion: As the "elevated loneliness" class was at the highest risk of mental dysfunction, our findings underscore the importance of identifying those individuals to implement counteractive measures.
Databáze: MEDLINE
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