Normal glucose tolerant women with low glycemia during the oral glucose tolerance test have a higher risk to deliver a low birth weight infant.

Autor:	Raets L; Department of Endocrinology, University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium., Van Doninck L; Medicine, KU Leuven, Leuven, Belgium., Van Crombrugge P; Department of Endocrinology, Onze-Lieve-Vrouwziekenhuis (OLV) Ziekenhuis Aalst-Asse-Ninove, Aalst, Belgium., Moyson C; Department of Endocrinology, University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium., Verhaeghe J; Department of Obstetrics & Gynecology, Universitair Ziekenhuis (UZ) Gasthuisberg, KU Leuven, Leuven, Belgium., Vandeginste S; Department of Obstetrics & Gynecology, Onze-Lieve-Vrouwziekenhuis (OLV) Ziekenhuis Aalst-Asse-Ninove, Aalst, Belgium., Verlaenen H; Department of Obstetrics & Gynecology, Onze-Lieve-Vrouwziekenhuis (OLV) Ziekenhuis Aalst-Asse-Ninove, Aalst, Belgium., Vercammen C; Department of Endocrinology, Imelda Ziekenhuis, Bonheiden, Belgium., Maes T; Department of Endocrinology, Imelda Ziekenhuis, Bonheiden, Belgium., Dufraimont E; Department of Obstetrics & Gynecology, Imelda Ziekenhuis, Bonheiden, Belgium., Roggen N; Department of Obstetrics & Gynecology, Imelda Ziekenhuis, Bonheiden, Belgium., De Block C; Department of Endocrinology-Diabetology-Metabolism, Antwerp University Hospital, Edegem, Belgium., Jacquemyn Y; Department of Obstetrics & Gynecology, Antwerp University Hospital, Edegem, Belgium.; Antwerp Surgical Training, Anatomy and Research Centre (ASTARC) and Global Health Institute (GHI), Antwerp University University of Antwerp (UA), Antwerp, Belgium., Mekahli F; Department of Endocrinology, Kliniek St-Jan Brussel, Brussel, Belgium., De Clippel K; Department of Obstetrics & Gynecology, Kliniek St-Jan Brussel, Brussel, Belgium., Van Den Bruel A; Department of Endocrinology, Algemeen Ziekenhuis (AZ) St. Jan Brugge, Brugge, Belgium., Loccufier A; Department of Obstetrics & Gynecology, Algemeen Ziekenhuis (AZ) St. Jan Brugge, Brugge, Belgium., Laenen A; Center of Biostatics and Statistical bioinformatics, KU Leuven, Leuven, Belgium., Devlieger R; Department of Obstetrics & Gynecology, Universitair Ziekenhuis (UZ) Gasthuisberg, KU Leuven, Leuven, Belgium., Mathieu C; Department of Endocrinology, University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium., Benhalima K; Department of Endocrinology, University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2023 Jun 02; Vol. 14, pp. 1186339. Date of Electronic Publication: 2023 Jun 02 (Print Publication: 2023).
DOI:	10.3389/fendo.2023.1186339
Abstrakt:	Background: Data are limited on pregnancy outcomes of normal glucose tolerant (NGT) women with a low glycemic value measured during the 75g oral glucose tolerance test (OGTT). Our aim was to evaluate maternal characteristics and pregnancy outcomes of NGT women with low glycemia measured at fasting, 1-hour or 2-hour OGTT. Methods: The Belgian Diabetes in Pregnancy-N study was a multicentric prospective cohort study with 1841 pregnant women receiving an OGTT to screen for gestational diabetes (GDM). We compared the characteristics and pregnancy outcomes in NGT women according to different groups [(<3.9mmol/L), (3.9-4.2mmol/L), (4.25-4.4mmol/L) and (>4.4mmol/L)] of lowest glycemia measured during the OGTT. Pregnancy outcomes were adjusted for confounding factors such as body mass index (BMI) and gestational weight gain. Results: Of all NGT women, 10.7% (172) had low glycemia (<3.9 mmol/L) during the OGTT. Women in the lowest glycemic group (<3.9mmol/L) during the OGTT had compared to women in highest glycemic group (>4.4mmol/L, 29.9%, n=482), a better metabolic profile with a lower BMI, less insulin resistance and better beta-cell function. However, women in the lowest glycemic group had more often inadequate gestational weight gain [51.1% (67) vs. 29.5% (123); p<0.001]. Compared to the highest glycemia group, women in the lowest group had more often a birth weight <2.5Kg [adjusted OR 3.41, 95% CI (1.17-9.92); p=0.025]. Conclusion: Women with a glycemic value <3.9 mmol/L during the OGTT have a higher risk for a neonate with birth weight < 2.5Kg, which remained significant after adjustment for BMI and gestational weight gain. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Raets, Van Doninck, Van Crombrugge, Moyson, Verhaeghe, Vandeginste, Verlaenen, Vercammen, Maes, Dufraimont, Roggen, De Block, Jacquemyn, Mekahli, De Clippel, Van Den Bruel, Loccufier, Laenen, Devlieger, Mathieu and Benhalima.)
Databáze:	MEDLINE
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