Research note: Occurrence of mcr- encoded colistin resistance in Escherichia coli from pigs and pig farm workers in Vietnam.

Autor:	Dang STT; National Institute of Veterinary Research, 74 Truong Chinh, Phuong Dinh, Dong Da, Hanoi, Vietnam., Truong DTQ; National Institute of Veterinary Research, 74 Truong Chinh, Phuong Dinh, Dong Da, Hanoi, Vietnam., Olsen JE; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Stigboejlen 4, Frederiksberg C 1870, Denmark., Tran NT; National Institute of Veterinary Research, 74 Truong Chinh, Phuong Dinh, Dong Da, Hanoi, Vietnam., Truong GTH; National Institute of Veterinary Research, 74 Truong Chinh, Phuong Dinh, Dong Da, Hanoi, Vietnam., Vu HTK; National Institute of Veterinary Research, 74 Truong Chinh, Phuong Dinh, Dong Da, Hanoi, Vietnam., Dalsgaard A; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Stigboejlen 4, Frederiksberg C 1870, Denmark.; School of Chemical and Biomedical Engineering Nanyang Technological University, 62 Nanyang Drive Singapore 637459.
Jazyk:	angličtina
Zdroj:	FEMS microbes [FEMS Microbes] 2020 Oct 09; Vol. 1 (1), pp. xtaa003. Date of Electronic Publication: 2020 Oct 09 (Print Publication: 2020).
DOI:	10.1093/femsmc/xtaa003
Abstrakt:	WHO considers colistin as a highest priority critically important drug for human health, and occurrence of colistin-resistant bacteria in livestock is of health concern. The current study determined occurrence of colistin-resistant Escherichia coli in pigs and workers at pig farms in Vietnam, and investigated the genetic background for resistance. Colistin-resistant E. coli were detected from pigs in 53/116 (45.7%) farms, and from workers taking care of the pigs in 21/94 (22.3%) farms. Colistin-resistant isolates showed MIC to colistin between 4-16 mg/L, they were multidrug resistant (99%) and resistance was caused by the presence of mcr-1 genes in 97/102 (95.1%) E. coli from pigs and in 31/34 (91.1%) isolates from humans. mcr-1 is considered a plasmid-encoded gene, but this was not confirmed in the current investigation. In total, one pig isolate carried both mcr-1 and mcr-3 genes, whereas mcr-2, mcr-4 and mcr-5 genes were not detected. Shared resistance profiles between pig and human isolates on the same farm was only observed in four farms. The study showed that commensal E. coli from pigs in Vietnam constitute a reservoir for colistin-resitant E. coli , however, further studies are needed to confirm that mcr genes are associated with plasmids and their importance for human health. Competing Interests: None declared. (© The Author(s) 2020. Published by Oxford University Press on behalf of FEMS.)
Databáze:	MEDLINE
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