Efficacy of resveratrol in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials.
| Autor: | Ali Fadlalmola H; Nursing College, Taibah University, Madinah, Saudi Arabia., Elhusein AM; College of Applied Medical Science, University of Bisha, Bisha, Saudi Arabia., Al-Sayaghi KM; Nursing College, Taibah University, Madinah, Saudi Arabia., Albadrani MS; College of Medicine, Taibah University, Madinah, Saudi Arabia., Swamy DV; College of Applied Medical Science, University of Bisha, Bisha, Saudi Arabia., Mamanao DM; Nursing College, Taibah University, Madinah, Saudi Arabia., El-Amin EI; Jazan University, Faculty of Public Health and Tropical Medicine, Department of Epidemiology, Jazan, Saudi Arabia., Ibrahim SE; Umm Alqura University, Faculty of Medicine, Algunfudah, Saudi Arabia., Abbas SM; Umm Alqura University, Faculty of Medicine, Algunfudah, Saudi Arabia. |
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| Jazyk: | angličtina |
| Zdroj: | The Pan African medical journal [Pan Afr Med J] 2023 Mar 16; Vol. 44, pp. 134. Date of Electronic Publication: 2023 Mar 16 (Print Publication: 2023). |
| DOI: | 10.11604/pamj.2023.44.134.32404 |
| Abstrakt: | Polycystic ovarian syndrome (PCOS) is a metabolic and hormonal condition affecting women of a reproductive age. It causes an abnormal menstrual cycle, anovulation, infertility, acne, hirsutism, obesity, hyperlipidemia, and cardiovascular disorders. Because resveratrol decreases testosterone levels, it may be of value in treating PCOS. We aimed to evaluate the efficacy of resveratrol in treating women with PCOS. We searched for randomized clinical trials (RCTs) in PubMed, Cochrane CENTRAL, Scopus and Web of Science. With 95% confidence intervals, the data was retrieved and analyzed as a mean difference (MD) or a standardized mean difference (SMD). Four RCTs with 218 women were included in the analysis. Resveratrol significantly reduced testosterone (SMD = -0.40; 95% CI [-0.71, -0.10], P = 0.009), luteinizing hormone (LH) (SMD = -0.32; 95% CI [-0.62, 0.01], P = 0.04), and dehydroepiandrosterone sulfate (DHEAS) (MD = -0.85; 95% CI [-1.25, -0.45], P < 0.0001) compared with the placebo. Resveratrol is effective in treating women with PCOS due to reducing the levels of testosterone, LH, and DHEAS. In combination with other treatments, especially for hyperlipidemia, resveratrol is beneficial for women diagnosed with PCOS. Competing Interests: The authors declare no competing interests. (Copyright: Hammad Ali Fadlalmola et al.) |
| Databáze: | MEDLINE |
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