Gender-based heterogeneity of FAHFAs in trained runners.

Autor:	Nelson AB; Division of Molecular Medicine; Department of Medicine, University of Minnesota, Minneapolis, MN, 55455, USA., Chow LS; Division of Diabetes, Endocrinology and Metabolism; Department of Medicine, University of Minnesota, Minneapolis, MN, 55455, USA., Dengel DR; School of Kinesiology, University of Minnesota, Minneapolis, MN 55455., Pan M; Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.; Department of Medicine - Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Hughey CC; Division of Molecular Medicine; Department of Medicine, University of Minnesota, Minneapolis, MN, 55455, USA., Han X; Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.; Department of Medicine - Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Puchalska P; Division of Molecular Medicine; Department of Medicine, University of Minnesota, Minneapolis, MN, 55455, USA., Crawford PA; Division of Molecular Medicine; Department of Medicine, University of Minnesota, Minneapolis, MN, 55455, USA.; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 08. Date of Electronic Publication: 2023 Jun 08.
DOI:	10.1101/2023.06.07.543941
Abstrakt:	Fatty acid esters of hydroxy fatty acid (FAHFA) are anti-diabetic and anti-inflammatory lipokines. Recently FAHFAs were also found to predict cardiorespiratory fitness in trained runners. Here we compared the association between circulating FAHFA baseline concentrations and body composition, determined by dual x-ray absorptiometry, in female runners who were lean (BMI < 25 kg/m 2 , n = 6), to those who were overweight (BMI ≥ 25 kg/m 2 , n = 7). We also compared circulating FAHFAs in lean male runners (n = 8) to the same trained lean female (n = 6) runner group. Circulating FAHFAs were increased in females in a manner that was modulated by specific adipose depot sizes, blood glucose, and lean body mass. As expected, circulating FAHFAs were diminished in the overweight group, but, strikingly, in both lean and overweight cohorts, increases in circulating FAHFAs were promoted by increased fat mass, relative to lean mass. These studies suggest multimodal regulation of circulating FAHFAs and raise hypotheses to test endogenous FAHFA dynamic sources and sinks in health and disease, which will be essential for therapeutic target development. Baseline circulating FAHFA concentrations could signal sub-clinical metabolic dysfunction in metabolically healthy obesity. Competing Interests: Competing Interest Statement: P.A.C. has served as an external consultant for Pfizer, Inc., Abbott Laboratories, Janssen Research & Development and Juvenescence.
Databáze:	MEDLINE
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