Elevated Level of Glycated KQTALVELVK Peptide of Albumin Is Associated with the Risk of Diabetic Nephropathy.

Autor: Chaurasiya AH; Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune 411008, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Jaiswal MR; Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune 411008, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Bayatigeri S; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.; Center for Materials Characterization, CSIR-National Chemical Laboratory, Pune 411008, India., Kahar S; Department of Diabetes and Endocrine Research, Chellaram Diabetes Institute, Pune 411021, India., Tiwari S; Department of Diabetes and Endocrine Research, Chellaram Diabetes Institute, Pune 411021, India., Unnikrishnan AG; Department of Diabetes and Endocrine Research, Chellaram Diabetes Institute, Pune 411021, India., Kulkarni MJ; Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune 411008, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Jazyk: angličtina
Zdroj: ACS omega [ACS Omega] 2023 Jun 01; Vol. 8 (23), pp. 20654-20660. Date of Electronic Publication: 2023 Jun 01 (Print Publication: 2023).
DOI: 10.1021/acsomega.3c01219
Abstrakt: Diabetic nephropathy is a leading cause of end-stage renal disease. Hence, early detection of diabetic nephropathy is essential to mitigate the disease burden. Microalbuminuria, the currently used diagnostic marker of diabetic nephropathy, is not efficient in detecting it at an early stage. Therefore, we explored the utility of glycated human serum albumin (HSA) peptides for risk prediction of diabetic nephropathy. Three glycation-sensitive HSA peptides, namely, FKDLGEENFK, KQTALVELVK, and KVPQVSTPTLVEVSR, with deoxyfructosyllysine (DFL) modification were quantified by targeted mass spectrometry (MS) in a study population comprising healthy and type II diabetes subjects with and without nephropathy. Mass spectrometry, receiver operating characteristic (ROC) curve, and correlation analysis revealed that the DFL-modified KQTALVELVK peptide was better than other glycated HSA peptides and HbA 1c for identifying diabetic nephropathy. DFL-modified KQTALVELVK could be a potential marker for risk prediction of diabetic nephropathy.
Competing Interests: The authors declare no competing financial interest.
(© 2023 The Authors. Published by American Chemical Society.)
Databáze: MEDLINE
Externí odkaz: