Metastatic solid tumors to the testis: a clinicopathologic evaluation of 157 cases from an international collaboration.

Autor: Nova-Camacho LM; Department of Pathology, Donostia University Hospital, San Sebastian 20014, Spain. Electronic address: luismi_15_16@hotmail.com., Acosta AM; Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA; Department of Pathology, Faulkner Hospital, Boston, MA 02130, USA., Trpkov K; Department of Pathology and Laboratory Medicine, University of Calgary, Calgary T2V 1P9, Canada., Sangoi AR; Department of Pathology, El Camino Hospital, Mountain View, CA 94040, USA., Pierre A; Department of Pathology, CHU Rennes - Hôpital Pontchaillou, Rennes 35000, France., Chou A; Department of Anatomical Pathology, Royal North Shore Hospital and University of Sydney, Sydney 2065, Australia., Yilmaz A; Department of Pathology and Laboratory Medicine, University of Calgary, Calgary T2V 1P9, Canada., Morini A; Department of Pathology, Grand Hôpital de L'Est Francilien, Jossigny, Ile-de-France 77600, France., Rodrigues Â; Department of Pathology, Portuguese Oncology Institute of Porto, Porto 4200-072, Portugal., Fletcher CDM; Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA., Perez-Montiel D; Department of Pathology, Instituto Nacional de Cancerología, Mexico City 14080, Mexico., Maclean F; Department of Pathology and Laboratory Medicine, Douglass Hanly Moir Pathology, Sonic Healthcare, Sydney 2000, Australia., Contreras F; Laboratorio de Patología, Clínica Universitaria Unión Médica, PUCMM, Santiago 51000, Dominican Republic., Queipo FJ; Department of Pathology, San Jorge University Hospital, Huesca 22004, Spain., Muñiz Unamunzaga G; Department of Pathology, San Jorge University Hospital, Huesca 22004, Spain., Mesa H; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA., de Torres I; Department of Pathology, Vall D'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona 08035, Spain., Ruiz I; Department of Pathology, Donostia University Hospital, San Sebastian 20014, Spain., Alvarado-Cabrero I; Department of Pathology Oncology, Star Medica Hospital, Oncology Hospital, IMSS, Mexico City 03810, Mexico., Lobo J; Department of Pathology, Portuguese Oncology Institute of Porto, Porto 4200-072, Portugal; Cancer Biology and Epigenetics Group, IPO Porto Research Center (GEBC CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto) & Porto Comprehensive Cancer Center (P.CCC), Porto 4200-072, Portugal; Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UP), Porto 4050-313, Portugal., Schwartz L; Department of Pathology, University of Pennsylvania, Philadelphia, PA 19104, USA., Cheng L; Department of Pathology and Laboratory Medicine, Brown University Warren Alpert Medical School, Providence, RI 02903, USA., Akgul M; Department of Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY 12208, USA., García-Martos M; Department of Pathology, Gregorio Marañón University Hospital, Madrid 28007, Spain., Palmer MB; Department of Pathology, University of Pennsylvania, Philadelphia, PA 19104, USA., Aron M; Department of Pathology and Laboratory Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Raspollini MR; Histopathology and Molecular Diagnostics, Careggi University Hospital, Florence 50134, Italy., Manrique Celada M; Department of Pathology, Donostia University Hospital, San Sebastian 20014, Spain., Hwang M; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Idrees MT; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Rioux-Leclercq N; Department of Pathology, CHU Rennes - Hôpital Pontchaillou, Rennes 35000, France., Zalles N; Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH 44106, USA., Vergara N; Department of Pathology, University of Pennsylvania, Philadelphia, PA 19104, USA., Lal P; Department of Pathology, University of Pennsylvania, Philadelphia, PA 19104, USA., Wobker S; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Kammerer-Jacquet SF; Department of Pathology, CHU Rennes - Hôpital Pontchaillou, Rennes 35000, France., Prendeville S; Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5S 1A1, Canada., Tilmant T; Department of Pathology, European Georges Pompidou Hospital, Université Paris-Cité, Paris 75015, France., Ulbright TM; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Verkarre V; Department of Pathology, European Georges Pompidou Hospital, Université Paris-Cité, Paris 75015, France., Collins K; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Williamson SR; Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH 44106, USA., Panizo A; Department of Pathology, University Hospital of Navarra, Pamplona 31008, Spain.
Jazyk: angličtina
Zdroj: Human pathology [Hum Pathol] 2023 Sep; Vol. 139, pp. 37-46. Date of Electronic Publication: 2023 Jun 16.
DOI: 10.1016/j.humpath.2023.06.002
Abstrakt: To elucidate the spectrum of metastatic solid tumors to the testis and their clinicopathologic features. The databases and files of 26 pathology departments from 9 countries on 3 continents were surveyed to identify metastatic solid tumors to the testis and to characterize their clinicopathologic features in detail. We compiled a series of 157 cases of metastatic solid tumors that secondarily involved the testis. The mean patient age at diagnosis was 64 years (range, 12-93 years). Most patients (127/144; 88%) had clinical manifestation of the disease, with testicular mass/nodule (89/127; 70%) being the most common finding. The main mechanism of testicular involvement was metastasis in 154/157 (98%) cases. Bilateral testicular involvement was present in 12/157 (8%) patients. Concurrent or prior extratesticular metastases were present in 78/101 (77%) patients. The diagnosis was made mainly in orchiectomy specimens (150/157; 95%). Different types of carcinomas (138/157; 87%), most commonly adenocarcinoma (72/157; 46%), were the most common malignancies. The most common primary carcinomas included prostatic (51/149; 34%), renal (29/149; 20%), and colorectal (13/149; 9%). Intratubular growth was identified in 13/124 (11%) cases and paratesticular involvement was found in 73/152 (48%) cases. In patients with available follow-up (110/157; 70%), more than half (58/110; 53%) died of disease. In this largest series compiled to date, we found that most secondary tumors of the testis represent metastases from the genitourinary and gastrointestinal tract carcinomas and typically occur in the setting of disseminated disease.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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