Efficacy of ultraviolet B radiation versus vitamin D 3 on postural control and cognitive functions in relapsing-remitting multiple sclerosis: A randomized controlled study.

Autor: Essa SA; Department of Basic Sciences, Faculty of Physical Therapy, Suez University, Suez Governorate, Egypt. Electronic address: s.essa@the.suezuni.edu.eg., Elokda A; Department of Cardiopulmonary Rehabilitation, Faculty of Physical Therapy, Cairo University, Giza, Egypt. Electronic address: aelokda@fgcu.edu., Mosaad D; Department of Basic Sciences, Faculty of Physical Therapy, Cairo University, Giza, Egypt. Electronic address: drdaliamosaad@gmail.com., Shendy W; Department of Neurological Disorders and Its Surgery, Faculty of Physical Therapy, Cairo University, Giza, Egypt. Electronic address: dr_shendy@hotmail.com., Abdel-Nasser M; Department of Neurology, Faculty of Medicine, Cairo University, Giza, Egypt. Electronic address: Magednaseer@hotmail.com., Ebraheim AM; Department of Neurology, Faculty of Medicine, Cairo University, Giza, Egypt. Electronic address: Asmaa.ebraheim@kasralainy.edu.eg., Mohammad H; Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Giza, Egypt. Electronic address: Hadeel.mohammad@gmail.com., Elmazny A; Department of Neurology, Faculty of Medicine, Cairo University, Giza, Egypt. Electronic address: Alaa_elmazny@kasralainy.edu.eg., Magdy E; Department of Neurology, Police Forces Hospital, Giza, Egypt. Electronic address: Dr_eman_magdy@yahoo.com.
Jazyk: angličtina
Zdroj: Journal of bodywork and movement therapies [J Bodyw Mov Ther] 2023 Jul; Vol. 35, pp. 49-56. Date of Electronic Publication: 2023 Apr 17.
DOI: 10.1016/j.jbmt.2023.04.069
Abstrakt: Background: The relapsing-remitting multiple sclerosis (RRMS) is the most common type of MS with prevalence rate 20-60 patients/100.000 individuals in Egypt. Poor postural control and cognitive dysfunctions are well-established complications of RRMS without potent remedy yet. The latest evidence highlighted the potential and independent immune-modulating effects of vitamin D 3 and ultraviolet radiation in the management of RRMS.
Objective: To investigate the efficacy of broadband ultraviolet B radiation (UVBR) versus moderate loading dose of vitamin D 3 supplementation in improving postural control and cognitive functions.
Design: Pretest-posttest randomized controlled study.
Setting: Multiple sclerosis outpatient unit of Kasr Al-Ainy Hospital.
Participants: Forty-seven patients with RRMS were recruited from both genders, yet only 40 completed the study.
Interventions: Patients were randomized into two groups: UVBR group involved 24 patients, received sessions for 4 weeks and vitamin D 3 group involved 23 patients, took vitamin D 3 supplementation (50 000 IU/week) for 12 weeks.
Main Outcome Measures: Overall balance system index (OSI) and symbol digit modalities test (SDMT).
Results: Highly significant decrease (P < 0.001) of the OSI in both groups post-treatment, indicating improved postural control. Moreover, highly significant improvement in the SDMT scores was noted, indicating information processing speed enhancement. Nonetheless, no statistically significant (P ≥ 0.05) differences were evident between the two groups post-treatment in all tested measures.
Conclusion: Both therapeutic programs were statistically equal in improving postural control and cognitive functions. However, clinically, UVBR therapy was more convenient owing to its shorter treatment time and higher percentage of change for all tested measures.
Competing Interests: Declaration of competing interest Authors declare no conflict of interest.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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