Alveolar macrophages from EVALI patients and e-cigarette users: a story of shifting phenotype.

Autor: Warren KJ; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA. kristi.warren@hsc.utah.edu.; George E. Wahlen VA Medical Center, 500 Foothill Dr, Salt Lake City, UT, 84148, USA. kristi.warren@hsc.utah.edu., Beck EM; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA.; George E. Wahlen VA Medical Center, 500 Foothill Dr, Salt Lake City, UT, 84148, USA., Callahan SJ; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA.; George E. Wahlen VA Medical Center, 500 Foothill Dr, Salt Lake City, UT, 84148, USA., Helms MN; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA., Middleton E; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA., Maddock S; George E. Wahlen VA Medical Center, 500 Foothill Dr, Salt Lake City, UT, 84148, USA.; Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, CO, 80206, USA., Carr JR; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA.; Intermountain Healthcare, Department of Pulmonary & Critical Care Medicine, Murray, UT, 84107, USA., Harris D; Intermountain Healthcare, Department of Pulmonary & Critical Care Medicine, Murray, UT, 84107, USA., Blagev DP; Intermountain Healthcare, Department of Pulmonary & Critical Care Medicine, Murray, UT, 84107, USA., Lanspa MJ; Intermountain Healthcare, Department of Pulmonary & Critical Care Medicine, Murray, UT, 84107, USA., Brown SM; Intermountain Healthcare, Department of Pulmonary & Critical Care Medicine, Murray, UT, 84107, USA., Paine R 3rd; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA.; George E. Wahlen VA Medical Center, 500 Foothill Dr, Salt Lake City, UT, 84148, USA.
Jazyk: angličtina
Zdroj: Respiratory research [Respir Res] 2023 Jun 17; Vol. 24 (1), pp. 162. Date of Electronic Publication: 2023 Jun 17.
DOI: 10.1186/s12931-023-02455-w
Abstrakt: Exposure to e-cigarette vapors alters important biologic processes including phagocytosis, lipid metabolism, and cytokine activity in the airways and alveolar spaces. Little is known about the biologic mechanisms underpinning the conversion to e-cigarette, or vaping, product use-associated lung injury (EVALI) from normal e-cigarette use in otherwise healthy individuals. We compared cell populations and inflammatory immune populations from bronchoalveolar lavage fluid in individuals with EVALI to e-cigarette users without respiratory disease and healthy controls and found that e-cigarette users with EVALI demonstrate a neutrophilic inflammation with alveolar macrophages skewed towards inflammatory (M1) phenotype and cytokine profile. Comparatively, e-cigarette users without EVALI demonstrate lower inflammatory cytokine production and express features associated with a reparative (M2) phenotype. These data indicate macrophage-specific changes are occurring in e-cigarette users who develop EVALI.
(© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze: MEDLINE
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