Mechanistic insight and structure activity relationship of isatin-based derivatives in development of anti-breast cancer agents.

Autor: Singh A; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India. atampanesar@gmail.com., Singh K; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India., Sharma A; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India., Sharma S; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India., Batra K; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India., Joshi K; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India., Singh B; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India., Kaur K; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India., Chadha R; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India., Bedi PMS; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India. bedi_preet@yahoo.com.; Drug and Pollution Testing Laboratory, Guru Nanak Dev University, Amritsar, Punjab, 143005, India. bedi_preet@yahoo.com.
Jazyk: angličtina
Zdroj: Molecular and cellular biochemistry [Mol Cell Biochem] 2024 May; Vol. 479 (5), pp. 1165-1198. Date of Electronic Publication: 2023 Jun 17.
DOI: 10.1007/s11010-023-04786-0
Abstrakt: Breast cancer is most common in women and most difficult to manage that causes highest mortality and morbidity among all diseases and posing significant threat to mankind as well as burden on healthcare system. In 2020, 2.3 million women were diagnosed with breast cancer and it was responsible for 685,000 deaths globally, suggesting the severity of this disease. Apart from that, relapsing of cases and resistance among available anticancer drugs along with associated side effects making the situation even worse. Therefore, it is a global emergency to develop potent and safer antibreast cancer agents. Isatin is most versatile and flying one nucleus which is an integral competent and various anticancer agent in clinical practice and widely used by various research groups around the globe for development of novel, potent, and safer antibreast cancer agents. This review will shed light on the structural insights and antiproliferative potential of various isatin-based derivatives developed for targeting breast cancer in last three decades that will help researchers in design and development of novel, potent, and safer isatin-based antibreast cancer agents.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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