Machine learning-based protein signatures for differentiating hypertensive disorders of pregnancy.

Autor: Varghese B; Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, Guwahati, Sila katamur Village, Changsari, Assam, India., Joy CA; Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, Guwahati, Sila katamur Village, Changsari, Assam, India., Josyula JVN; Applied Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, India., Jangili S; Applied Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, India., Talukdar RK; Department of Obstetrics and Gynecology, Gauhati Medical College, Guwahati, India., Mutheneni SR; Applied Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, India., Adela R; Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, Guwahati, Sila katamur Village, Changsari, Assam, India. ramu@niperguwahati.in.
Jazyk: angličtina
Zdroj: Hypertension research : official journal of the Japanese Society of Hypertension [Hypertens Res] 2023 Nov; Vol. 46 (11), pp. 2513-2526. Date of Electronic Publication: 2023 Jun 16.
DOI: 10.1038/s41440-023-01348-1
Abstrakt: Hypertensive disorders of pregnancy (HDP) result in major maternal and fetal complications. Our study aimed to find a panel of protein markers to identify HDP by applying machine-learning models. The study was conducted on a total of 133 samples, divided into four groups, healthy pregnancy (HP, n = 42), gestational hypertension (GH, n = 67), preeclampsia (PE, n = 9), and ante-partum eclampsia (APE, n = 15). Thirty circulatory protein markers were measured using Luminex multiplex immunoassay and ELISA. Significant markers were screened for potential predictive markers by both statistical and machine-learning approaches. Statistical analysis found seven markers such as sFlt-1, PlGF, endothelin-1(ET-1), basic-FGF, IL-4, eotaxin and RANTES to be altered significantly in disease groups compared to healthy pregnant. Support vector machine (SVM) learning model classified GH and HP with 11 markers (eotaxin, GM-CSF, IL-4, IL-6, IL-13, MCP-1, MIP-1α, MIP-1β, RANTES, ET-1, sFlt-1) and HDP with 13 markers (eotaxin, G-CSF, GM-CSF, IFN-gamma, IL-4, IL-5, IL-6, IL-13, MCP-1, MIP-1β, RANTES, ET-1, sFlt-1). While logistic regression (LR) model classified PE with 13 markers (basic FGF, IL-1β, IL-1ra, IL-7, IL-9, MIP-1β, RANTES, TNF-alpha, nitric oxide, superoxide dismutase, ET-1, PlGF, sFlt-1) and APE by 12 markers (eotaxin, basic-FGF, G-CSF, GM-CSF, IL-1β, IL-5, IL-8, IL-13, IL-17, PDGF-BB, RANTES, PlGF). These markers may be used to diagnose the progression of healthy pregnant to a hypertensive state. Future longitudinal studies with large number of samples are needed to validate these findings.
(© 2023. The Author(s), under exclusive licence to The Japanese Society of Hypertension.)
Databáze: MEDLINE
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