Reversing the mitochondrial hex that bewitches NLRP3.
| Autor: | Mellacheruvu M; Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD, Australia., Lawrence GMEP; Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD, Australia., Emming S; Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD, Australia., Schroder K; Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD, Australia. |
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| Jazyk: | angličtina |
| Zdroj: | Science immunology [Sci Immunol] 2023 Jun 23; Vol. 8 (84), pp. eadh2967. Date of Electronic Publication: 2023 Jun 16. |
| DOI: | 10.1126/sciimmunol.adh2967 |
| Abstrakt: | Hexokinase dissociation from mitochondria triggers calcium-induced oligomerization of VDAC within the outer mitochondrial membrane, leading to NLRP3 recruitment and inflammasome signaling (see related Research Article by Baik et al. ). |
| Databáze: | MEDLINE |
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