Role of Iron Accumulation in Osteoporosis and the Underlying Mechanisms.
Autor: | Li GF; Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, 2015004, China.; Osteoporosis Institute of Soochow University, Suzhou, 215004, China., Gao Y; Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, 2015004, China.; Osteoporosis Institute of Soochow University, Suzhou, 215004, China., Weinberg ED; Department of Biology & Program in Medical Sciences, Indiana University, Bloomington, IN, 47405, USA., Huang X; Department of Environmental Medicine, New York University, School of Medicine, New York, NY, 10016, USA., Xu YJ; Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, 2015004, China. xuyoujia@suda.edu.cn.; Osteoporosis Institute of Soochow University, Suzhou, 215004, China. xuyoujia@suda.edu.cn. |
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Jazyk: | angličtina |
Zdroj: | Current medical science [Curr Med Sci] 2023 Aug; Vol. 43 (4), pp. 647-654. Date of Electronic Publication: 2023 Jun 16. |
DOI: | 10.1007/s11596-023-2764-z |
Abstrakt: | Osteoporosis is prevalent in postmenopausal women. The underlying reason is mainly estrogen deficiency, but recent studies have indicated that osteoporosis is also associated with iron accumulation after menopause. It has been confirmed that some methods of decreasing iron accumulation can improve the abnormal bone metabolism associated with postmenopausal osteoporosis. However, the mechanism of iron accumulation-induced osteoporosis is still unclear. Iron accumulation may inhibit the canonical Wnt/β-catenin pathway via oxidative stress, leading to osteoporosis by decreasing bone formation and increasing bone resorption via the osteoprotegerin (OPG)/receptor activator of nuclear factor kappa-B ligand (RANKL)/receptor activator of nuclear factor kappa-B (RANK) system. In addition to oxidative stress, iron accumulation also has been reported to inhibit either osteoblastogenesis or osteoblastic function as well as to stimulate either osteoclastogenesis or osteoclastic function directly. Furthermore, serum ferritin has been widely used for the prediction of bone status, and nontraumatic measurement of iron content by magnetic resonance imaging may be a promising early indicator of postmenopausal osteoporosis. (© 2023. Huazhong University of Science and Technology.) |
Databáze: | MEDLINE |
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