The use of statins is related to a lower PSA level after endoscopic enucleation of the prostate with holmium laser (HoLEP) for the treatment of BPH.

Autor: Suartz CV; Division of Urology, Clinics Hospital, University of São Paulo Medical School, São Paulo, Brazil. caio.v_suartz@hotmail.com.; Divisão de Clínica Urológica, Hospital das Clínicas da Universidade de São Paulo, Avenida Dr. Éneas de Carvalho Aguiar, 255-Sala 710F, 7º Andar, São Paulo, SP, CEP 05403-000, Brasil. caio.v_suartz@hotmail.com., Braz NDSF; Division of Urology, Clinics Hospital, University of São Paulo Medical School, São Paulo, Brazil., Dos Anjos GC; Division of Urology, Clinics Hospital, University of São Paulo Medical School, São Paulo, Brazil., Dos Reis ST; Division of Urology, Clinics Hospital, University of São Paulo Medical School, São Paulo, Brazil., Nahas WC; Division of Urology, Clinics Hospital, University of São Paulo Medical School, São Paulo, Brazil., Antunes AA; Division of Urology, Clinics Hospital, University of São Paulo Medical School, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: World journal of urology [World J Urol] 2023 Aug; Vol. 41 (8), pp. 2149-2154. Date of Electronic Publication: 2023 Jun 16.
DOI: 10.1007/s00345-023-04462-4
Abstrakt: Objective: To determine the factors that may be associated with a 2-month high baseline level of Total Prostatic Specific Antigen (PSA) after endoscopic enucleation of the prostate with Holmium Laser (HoLEP).
Materials and Methods: Retrospective study of a prospectively collected database of adult males undergoing HoLEP at a single tertiary institution from September 2015 to February 2021. Pre-operative epidemiological, clinical characteristics and post-operative factors were analyzed and a multivariate analysis was performed to determine factors independently related to PSA decline.
Results: A total of 175 men aged 49-92 years with a prostate size ranging from 25 to 450 cc underwent HoLEP, and after excluding data from patients due to loss of follow-up or incomplete data, 126 patients were included in the final analysis. The patients were divided into group A (n = 84), which included patients with postoperative PSA nadir lower than 1 ng/ml, and group B(n = 42), with postoperative PSA levels greater than 1 ng/ml. In the univariate analysis there was a correlation between the variation of the PSA value and the percentage of resected tissue (p = 0.028), for each 1 g of resected prostate there was a reduction of 0.104 ng/mL, furthermore there was a difference between the means of age of group A (71.56 years) and group B (68.17 years) (p = 0.042). In the multivariate analysis, the use of statins and lower postoperative PSA levels (p = 0.024; HR = 3.71) were correlated.
Conclusions: Our results indicate that PSA after HoLEP is correlated with patient's age, the presence of incidental prostate cancer, and the use of statins.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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