Cognitive disorders in patients with chronic kidney disease: Approaches to prevention and treatment.

Autor: Pépin M; INSERM (Institut National de la Santé et de la recherche médicale) Unit 1018, Clinical Epidemiology, CESP (Centre d'Epidemiologie et de Santé des Populations), Hôpital Paul Brousse, Paris-Saclay University and Versailles Saint-Quentin-en-Yvelines University, Villejuif, France.; Department of Geriatrics, Ambroise Paré University Hospital, APHP (Assistance Publique - Hôpitaux de Paris), Boulogne-Billancourt/Paris, France., Klimkowicz-Mrowiec A; Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Cracow, Poland., Godefroy O; Department of Neurology, Amiens University Hospital, and Laboratory of Functional Neurosciences (Research Unit 4559), Jules Verne University of Picardie (UPJV), Amiens, France., Delgado P; Department of Neurology, Vall d'Hebron Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain., Carriazo S; Department of Nephrology and Hypertension, Instituto de Investigacion Sanitaria (IIS)-Fundacion Jimenez Diaz, Autonomous University of Madrid (UAM), Madrid, Spain., Ferreira AC; Department of Nephrology, Centro Hospitalar e Universitário de Lisboa Central-Hospital Curry Cabral, Lisbon, Portugal.; Universidade Nova de Lisboa-Faculdade de Ciências Médicas-Nephology, Lisbon, Portugal., Golenia A; Department of Neurology, Medical University of Warsaw, Warsaw, Poland., Malyszko J; Department of Nephrology, Dialysis, and Internal Medicine, Medical University of Warsaw, Warsaw, Poland., Grodzicki T; Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Cracow, Poland., Giannakou K; Department of Health Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus., Paolisso G; Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy.; UniCAMILLUS, International Medical University, Roma, Italy., Barbieri M; Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy., Garneata L; Department of Internal Medicine and Nephrology, 'Carol Davila' University of Medicine and Pharmacy, 'Dr Carol Davila' Teaching Hospital of Nephrology, Bucharest, Romania., Mocanu CA; Department of Internal Medicine and Nephrology, 'Carol Davila' University of Medicine and Pharmacy, 'Dr Carol Davila' Teaching Hospital of Nephrology, Bucharest, Romania., Liabeuf S; Pharmacology Department, Amiens University Medical Center, Amiens, France.; MP3CV (Mécanismes physiopathologiques et Conséquences des Calcifications Cardio-Vasculaires) Laboratory, EA7517, University of Picardie Jules Verne, Amiens, France., Spasovski G; University Department of Nephrology, Clinical Center 'Mother Theresa', University of Saints Cyril and Methodius, Skopje, North Macedonia., Zoccali C; Renal Research Institute, New York, New York, USA.; Associazione Ipertensione Nefrologia Trapianto Renale, Reggio Calabria, Italy., Bruchfeld A; Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden.; CLINTEC, Renal Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden., Farinha A; Department of Nephrology, Centro Hospitalar de Setúbal, Setubal, Portugal., Arici M; Department of Internal Medicine, Division of Nephrology, Hacetepe University, Faculty of Medicine, Ankara, Turkey., Capasso G; Biogem (Molecular Biology and Genetics Research Institute), Ariano Irpino, Italy.; Department of Translational Medical Sciences, University of Campania, Naples, Italy., Wiecek A; Department of Nephrology, Transplantation, and Internal Medicine, Medical University of Silesia in Katowice, Katowice, Poland., Massy ZA; INSERM (Institut National de la Santé et de la recherche médicale) Unit 1018, Clinical Epidemiology, CESP (Centre d'Epidemiologie et de Santé des Populations), Hôpital Paul Brousse, Paris-Saclay University and Versailles Saint-Quentin-en-Yvelines University, Villejuif, France.; Department of Nephrology, Ambroise Paré University Hospital, APHP, Boulogne-Billancourt/Paris, France.
Jazyk: angličtina
Zdroj: European journal of neurology [Eur J Neurol] 2023 Sep; Vol. 30 (9), pp. 2899-2911. Date of Electronic Publication: 2023 Jun 29.
DOI: 10.1111/ene.15928
Abstrakt: Background: Cognitive impairment is common in patients with chronic kidney disease (CKD), and early intervention may prevent the progression of this condition.
Methods: Here, we review interventions for the complications of CKD (anemia, secondary hyperparathyroidism, metabolic acidosis, harmful effects of dialysis, the accumulation of uremic toxins) and for prevention of vascular events, interventions that may potentially be protective against cognitive impairment. Furthermore, we discuss nonpharmacological and pharmacological methods to prevent cognitive impairment and/or minimize the latter's impact on CKD patients' daily lives.
Results: A particular attention on kidney function assessment is suggested during work-up for cognitive impairment. Different approaches are promising to reduce cognitive burden in patients with CKD but the availabe dedicated data are scarce.
Conclusions: There is a need for studies assessing the effect of interventions on the cognitive function of patients with CKD.
(© 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.)
Databáze: MEDLINE
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