MORPHOLOGICAL ASSESSMENT OF THE LUNGS IN POST-COVID-19 SYNDROME: ANALYSIS OF AUTOPSY MATERIAL.

Autor:	Myroshnychenko MS; KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE., Pasiyeshvili NM; PUBLIC NONPROFIT ORGANIZATION OF THE KHARKIV DISTRICT COUNCIL «REGIONAL CLINICAL PERINATAL CENTRE», KHARKIV, UKRAINE., Kapustnyk NV; PUBLIC NONPROFIT ORGANIZATION OF THE KHARKIV DISTRICT COUNCIL «REGIONAL CLINICAL PERINATAL CENTRE», KHARKIV, UKRAINE., Markovskiy VD; KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE., Kalashnyk-Vakulenko YM; KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE., Zaytseva OV; KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE., Bondarenko MA; KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE., Morozov OV; KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE., Molodan DV; KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
Jazyk:	angličtina
Zdroj:	Wiadomosci lekarskie (Warsaw, Poland : 1960) [Wiad Lek] 2023; Vol. 76 (5 pt 1), pp. 1014-1021.
DOI:	10.36740/WLek202305120
Abstrakt:	Objective: The aim was to reveal the morphological features of the lungs in post-COVID-19 syndrome. Patients and Methods: Materials and methods: The material of the study was autopsy material - fragments of the lung tissue from 96 deceased (59 men and 37 women). During the lifetime, all patients had in anamnesis COVID-19 of varying severity, and after the treatment of this infection, they had various manifestations of respiratory failure until death. The average duration of the post-COVID-19 period was 148.6±9.5 days. Based on the severity of COVID-19 in anamnesis, all cases were divided into three groups. Group 1 included 39 cases with mild COVID-19 in anamnesis. Group 2 included 24 cases with moderate severity of COVID-19 in an-amnesis. Group 3 included 33 cases with severe COVID-19 in anamnesis. Histological, histochemical, morphometric and statistical research methods were used. Results: Results: Morphological features of the lungs in post-COVID-19 syndrome were the presence of pneumosclerosis; focal-diffuse immune cells infiltration; emphysematous and atelectatic changes; degenerative-desquamatic changes in the alveolar epithelium; metaplastic changes of connective tissue; dystrophic calcification; dystrophic, metaplastic and dysplastic changes in the epithelial layer of bronchial tree; hemodynamic disorders. Pneumosclerosis, focal-diffuse immune cells infiltration, alterative changes in the alveolar epithelium, emphysematous and atelectatic changes, hemodynamic disorders increased with an increase the severity of COVID-19. Metaplastic changes of connective tissue, dystrophic calcification, dystrophic, metaplastic and dysplastic changes in epithelial layer of bronchial tree did not depend on the severity of the infection. Conclusion: Conclusions: The changes identified by the authors help to explain pulmonary manifestations of post-COVID-19 syndrome. They should be the basis for the oncological alertness formation among doctors, the development of rehabilitation and treatment measures for such category of patients.
Databáze:	MEDLINE
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