Cucumeropsis mannii seed oil ameliorates Bisphenol-A-induced adipokines dysfunctions and dyslipidemia.

Autor: Aja PM; Department of Biochemistry Ebonyi State University Abakaliki Nigeria.; Department of Biochemistry Mbarara University of Science and Technology (MUST) Mbarara Uganda.; Department of Biochemistry Kampala International University Bushenyi Uganda., Chiadikaobi CD; Department of Biochemistry Ebonyi State University Abakaliki Nigeria., Agu PC; Department of Biochemistry Ebonyi State University Abakaliki Nigeria., Ale BA; Department of Biochemistry University of Nigeria Nsukka Nigeria., Ani OG; Department of Public Health and Nutrition University of Chester Chester UK., Ekpono EU; Department of Biochemistry Mbarara University of Science and Technology (MUST) Mbarara Uganda., Ogwoni HA; Department of Biochemistry Ebonyi State University Abakaliki Nigeria., Awoke JN; Department of Biochemistry Ebonyi State University Abakaliki Nigeria., Ogbu PN; Department of Medical Biochemistry Alex-Ekwueme Federal University, Ndufu-Alike, Ikwo Abakaliki Ebonyi State Nigeria., Aja L; Department of Science Education Ebonyi State University Abakaliki Nigeria.; Department of Biochemistry Federal University of Health Sciences Otukpo Nigeria., Nwite FE; Department of Biochemistry Ebonyi State University Abakaliki Nigeria., Ukachi OU; Department of Biochemistry Ebonyi State University Abakaliki Nigeria., Orji OU; Department of Biochemistry Ebonyi State University Abakaliki Nigeria., Nweke PC; Department of Biochemistry Ebonyi State University Abakaliki Nigeria., Egwu CO; Department of Biochemistry University of Nigeria Nsukka Nigeria., Ekpono EU; Department of Biochemistry Ebonyi State University Abakaliki Nigeria., Ewa GO; Department of Biochemistry Ebonyi State University Abakaliki Nigeria., Igwenyi IO; Department of Biochemistry Ebonyi State University Abakaliki Nigeria., Tusubira D; Department of Biochemistry Mbarara University of Science and Technology (MUST) Mbarara Uganda., Offor CE; Department of Biochemistry Ebonyi State University Abakaliki Nigeria., Maduagwuna EK; Department of Biochemistry Ebonyi State University Abakaliki Nigeria., Alum EU; Department of Biochemistry Ebonyi State University Abakaliki Nigeria., Uti DE; Department of Science Laboratory Technology Federal Polytechnic Oko Oko Anambra State Nigeria., Njoku A; Department of Biochemistry Ebonyi State University Abakaliki Nigeria., Atoki VA; Department of Biochemistry Kampala International University Bushenyi Uganda., Awuchi CG; Department of Biochemistry Kampala International University Bushenyi Uganda.; School of Natural and Applied Sciences, Kampala International University Kampala Uganda.
Jazyk: angličtina
Zdroj: Food science & nutrition [Food Sci Nutr] 2023 Feb 18; Vol. 11 (6), pp. 2642-2653. Date of Electronic Publication: 2023 Feb 18 (Print Publication: 2023).
DOI: 10.1002/fsn3.3271
Abstrakt: This study demonstrated the therapeutic potentials of Cucumeropsis mannii seed oil (CMSO) capable of alleviating BPA-induced dyslipidemia and adipokine dysfunction. In this study, we evaluated the effects of CMSO on adipokine dysfunctions and dyslipidemia in bisphenol-A (BPA)-induced male Wistar rats. Six-week-old 36 albino rats of 100-200 g weight were assigned randomly to six groups, which received varied doses of BPA and/or CMSO. The administration of BPA and CMSO was done at the same time for 42 days by oral intubation. The adipokine levels and lipid profile were measured in adipose tissue and plasma using standard methods. BPA induced significant ( p  < .05) increases in triglycerides, cholesterol, leptin, LDL-C, and atherogenic and coronary risk indices in adipose tissue and plasma, as well as a decrease in adiponectin and HDL-C levels in Group II animals. BPA administration significantly ( p  < .05) elevated Leptin levels and reduced adiponectin levels. BPA plus CMSO reduced triglycerides, cholesterol, leptin, LDL-C, and atherogenic and coronary risk indices while increasing adiponectin levels and HDL-C in adipose tissue and plasma ( p  < .05). The results showed that BPA exposure increased adipose tissue as well as serum levels of the atherogenic index, triglycerides, cholesterol, coronary risk index, LDL-C, leptin, and body weight with decreased adiponectin levels and HDL-C. Treatment with CMSO reduced the toxicities caused by BPA in rats by modulating the body weight, adiponectin/leptin levels, and lipid profiles in serum and adipose tissue. This study has shown that CMSO ameliorates BPA-induced dyslipidemia and adipokine dysfunctions. We suggest for further clinical trial to establish the clinical applications.
Competing Interests: The authors declare no conflict of interest.
(© 2023 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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