Navigating the Complexities of Intraventricular Hemorrhage in Preterm Infants: An Updated Review.

Autor:	Apeksha Reddy P; Pediatric Medicine, P.E.S. Institute of Medical Sciences and Research, Kuppam, IND., Sreenivasulu H; General Medicine, P.E.S. Institute of Medical Sciences and Research, Kuppam, IND., Shokrolahi M; Internal Medicine, University of Debrecen, Debrecen, HUN., Muppalla SK; Pediatrics, P.E.S. Institute of Medical Sciences and Research, Kuppam, IND., Abdilov N; Internal Medicine, University of Debrecen, Debrecen, HUN., Ramar R; Internal Medicine, Rajah Muthiah Medical College and Hospital, Chidambaram, IND., Halappa Nagaraj R; Surgery, Avalon University School of Medicine, Willemstad, CUW., Vuppalapati S; Pediatrics, P.E.S. Institute of Medical Sciences and Research, Kuppam, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 May 13; Vol. 15 (5), pp. e38985. Date of Electronic Publication: 2023 May 13 (Print Publication: 2023).
DOI:	10.7759/cureus.38985
Abstrakt:	Intraventricular hemorrhage (IVH) is a type of bleeding that occurs in the ventricular cavity of the brain. In this comprehensive study, we provide a summary of the pathogenesis, diagnosis, and treatment of intraventricular hemorrhage in premature infants. Preterm babies are at high risk of developing IVH because their germinal matrix is not fully developed, making their blood vessels more prone to rupture. However, that is not necessarily the case in all preterm babies as the inherent structure of the germinal matrix makes it more susceptible to hemorrhage. Incidences of IVH are discussed based on recent data which states that around 12,000 premature infants in the United States experience IVH each year. Although grades I and II make up the majority of IVH cases and are frequently asymptomatic, IVH remains a significant issue for premature infants in neonatal intensive care facilities worldwide. Grades I and II have been linked to mutations in the type IV procollagen gene, COL4A1, as well as prothrombin G20210A and factor V Leiden mutations. Intraventricular hemorrhage can be detected using brain imaging in the first seven to 14 days following delivery. This review also shines a light on reliable methods for identifying IVH in premature newborns like cranial ultrasound and magnetic resonance imaging along with the treatment of IVH which is primarily supportive and involves the management of intracranial pressure, the correction of coagulation abnormalities, and the prevention of seizures. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Apeksha Reddy et al.)
Databáze:	MEDLINE
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