| Autor: |
Eyraud A, Descotes J, Lombard JY, Laschi-Loquerie A, Tachon P, Veysseyre C, Evreux JC |
| Jazyk: |
angličtina |
| Zdroj: |
Chemotherapy [Chemotherapy] 1986; Vol. 32 (4), pp. 379-82. |
| DOI: |
10.1159/000238438 |
| Abstrakt: |
The effects of three macrolide antibiotics were studied on rat polymorphonuclear leukocyte chemotaxis. Rats were given 25 mg/kg twice a day of either erythromycin, josamycin or spiramycin by gastric intubation for 5 days. In all cases, chemotaxis was found to be impaired by 10-20% only. As macrolides are known to reach high intracellular concentrations within polymorphonuclear leukocytes, our results suggest that these antibiotics are unlikely to exert a deleterious influence on the chemotactic response of treated patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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