Psychedelics reopen the social reward learning critical period.

Autor: Nardou R; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.; The Brain Science Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA., Sawyer E; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.; The Brain Science Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA., Song YJ; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.; The Brain Science Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA., Wilkinson M; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.; The Brain Science Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA., Padovan-Hernandez Y; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA., de Deus JL; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.; The Brain Science Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA., Wright N; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.; The Brain Science Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA., Lama C; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.; The Brain Science Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA., Faltin S; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.; The Brain Science Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA., Goff LA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.; Department of Oncology, Division of Biostatistics and Bioinformatics, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA., Stein-O'Brien GL; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.; The Brain Science Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.; The Kavli Neuroscience Discovery Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA., Dölen G; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA. gul@dolenlab.org.; The Brain Science Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA. gul@dolenlab.org.; The Kavli Neuroscience Discovery Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA. gul@dolenlab.org.; The Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA. gul@dolenlab.org.; The Center for Psychedelics and Consciousness Research, Johns Hopkins University, School of Medicine, Baltimore, MD, USA. gul@dolenlab.org.; The Wendy Klag Institute for Autism and Developmental Disabilities, Johns Hopkins University, School of Medicine, Baltimore, MD, USA. gul@dolenlab.org.
Jazyk: angličtina
Zdroj: Nature [Nature] 2023 Jun; Vol. 618 (7966), pp. 790-798. Date of Electronic Publication: 2023 Jun 14.
DOI: 10.1038/s41586-023-06204-3
Abstrakt: Psychedelics are a broad class of drugs defined by their ability to induce an altered state of consciousness 1,2 . These drugs have been used for millennia in both spiritual and medicinal contexts, and a number of recent clinical successes have spurred a renewed interest in developing psychedelic therapies 3-9 . Nevertheless, a unifying mechanism that can account for these shared phenomenological and therapeutic properties remains unknown. Here we demonstrate in mice that the ability to reopen the social reward learning critical period is a shared property across psychedelic drugs. Notably, the time course of critical period reopening is proportional to the duration of acute subjective effects reported in humans. Furthermore, the ability to reinstate social reward learning in adulthood is paralleled by metaplastic restoration of oxytocin-mediated long-term depression in the nucleus accumbens. Finally, identification of differentially expressed genes in the 'open state' versus the 'closed state' provides evidence that reorganization of the extracellular matrix is a common downstream mechanism underlying psychedelic drug-mediated critical period reopening. Together these results have important implications for the implementation of psychedelics in clinical practice, as well as the design of novel compounds for the treatment of neuropsychiatric disease.
(© 2023. The Author(s).)
Databáze: MEDLINE
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