Numerical simulations of fluid flow in trabecular-lacunar cavities under cyclic loading.

Autor: Zhao S; Biomechanics Lab, Department of Mechanics, School of Aerospace Engineering, Beijing Institute of Technology, Beijing, 100081, PR China., Chen Z; Biomechanics Lab, Department of Mechanics, School of Aerospace Engineering, Beijing Institute of Technology, Beijing, 100081, PR China., Li T; Biomechanics Lab, Department of Mechanics, School of Aerospace Engineering, Beijing Institute of Technology, Beijing, 100081, PR China., Sun Q; Biomechanics Lab, Department of Mechanics, School of Aerospace Engineering, Beijing Institute of Technology, Beijing, 100081, PR China., Leng H; Department of Orthopaedics, Peking University Third Hospital, Beijing, 100191, PR China., Huo B; Biomechanics Lab, Department of Mechanics, School of Aerospace Engineering, Beijing Institute of Technology, Beijing, 100081, PR China; Institute of Artificial Intelligence in Sports, Capital University of Physical Education and Sports, Beijing, 100091, PR China. Electronic address: huobo@cupes.edu.cn.
Jazyk: angličtina
Zdroj: Computers in biology and medicine [Comput Biol Med] 2023 Sep; Vol. 163, pp. 107144. Date of Electronic Publication: 2023 Jun 08.
DOI: 10.1016/j.compbiomed.2023.107144
Abstrakt: Background: Under external loading, the fluid shear stress (FSS) in the porous structures of bones, such as trabecular or lacunar-canalicular cavity, can influence the biological response of bone cells. However, few studies have considered both cavities. The present study investigated the characteristics of fluid flow at different scales in cancellous bone in rat femurs, as well as the effects of osteoporosis and loading frequency.
Methods: Sprague Dawley rats (3 months old) were divided into normal and osteoporotic groups. A multiscale 3D fluid-solid coupling finite element model considering trabecular system and lacunar-canalicular system was established. Cyclic displacement loadings with frequencies of 1, 2, and 4 Hz were applied.
Findings: Results showed that the wall FSS around the adhesion complexes of osteocyte on the canaliculi was higher than that on the osteocyte body. Under the same loading conditions, the wall FSS of the osteoporotic group was smaller than that of the normal group. The fluid velocity and FSS in trabecular pores exhibited a linear relationship with loading frequency. Similarly, the FSS around osteocytes also showed the loading frequency-dependent phenomenon.
Interpretation: The high cadence in movement can effectively increase the FSS level on osteocytes for osteoporotic bone, i.e., expand the space within the bone with physiological load. This study might help in understanding the process of bone remodeling under cyclic loading and provide the fundamental data for the development of strategies for osteoporosis treatment.
Competing Interests: Declaration of competing interest All authors have no conflicts of interest.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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