[Functional impairments in large-scale brain projects in opioid addiction].

Autor:	Abdulaev SK; Kirov Military Medical Academy, St. Petersburg, Russia., Tarumov DA; Kirov Military Medical Academy, St. Petersburg, Russia., Shamrey VK; Kirov Military Medical Academy, St. Petersburg, Russia., Trufanov AG; Kirov Military Medical Academy, St. Petersburg, Russia., Puchkov NA; Kirov Military Medical Academy, St. Petersburg, Russia., Markin KV; Kirov Military Medical Academy, St. Petersburg, Russia., Prochik YE; Kirov Military Medical Academy, St. Petersburg, Russia.
Jazyk:	ruština
Zdroj:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2023; Vol. 123 (5), pp. 165-170.
DOI:	10.17116/jnevro2023123051165
Abstrakt:	Objective: To assess the functional state of large-scale resting networks of the brain in patients with opioid intoxication. Material and Methods: Thirty-one male subjects, aged 27.4+5.1 years, were studied. Resting state functional MRI was performed in 12 patients with heroin intoxication aged 29.1+5.9 years. The control group consisted of 16 healthy volunteers without bad habits aged 26.2+4.2 years. Results: In the group of opioids intoxication, there is a decrease in the functional activity of the salience network with the executive control network and the default mode network of the brain ( p <0.05) compared to the control group. A positive correlation of functional connections is found between the anterior cingulate cortex and the medial prefrontal cortex (T=2.74; p =0.041), which is not recorded in the control group. The functional connections between the default mode network and executive control are more highly represented in opioid intoxication in comparison with the control group (medial prefrontal cortex - left posterior parietal cortex T=7.5; p =0.001; medial prefrontal cortex - right posterior parietal cortex T=3.71; p =0.014; posterior cingulate cortex - left posterior parietal cortex T=6.15; p =0.002; posterior cingulate cortex - right posterior parietal cortex T=3.25; p =0.023; posterior cingulate cortex - right dorsolateral prefrontal cortex T=2.83; p =0.037). Conclusion: The results indicate that functional connections in large-scale resting networks are disrupted during opioid intoxication, which indicates a disturbance of the normal functional architectonics of the brain.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu