Postabsorptive muscle protein synthesis is higher in outpatients as compared to inpatients.

Autor:	Reidy PT; Center for Metabolic Health, University of Texas Medical Branch, Galveston, Texas, United States.; Department of Kinesiology, Nutrition and Health, Miami University, Oxford, Ohio, United States., Borack MS; Center for Metabolic Health, University of Texas Medical Branch, Galveston, Texas, United States., Dickinson JM; Center for Metabolic Health, University of Texas Medical Branch, Galveston, Texas, United States., Carroll CC; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Burd NA; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Drummond MJ; Department of Physical Therapy & Athletic Training, University of Utah, Salt Lake City, Utah, United States.; Molecular Medicine Program, University of Utah, Salt Lake City, Utah, United States., Fry CS; Center for Metabolic Health, University of Texas Medical Branch, Galveston, Texas, United States.; Sealy Center on Aging, University of Texas Medical Branch, Galveston, Texas, United States., Lambert BS; Center for Metabolic Health, University of Texas Medical Branch, Galveston, Texas, United States., Gundermann DM; Center for Metabolic Health, University of Texas Medical Branch, Galveston, Texas, United States., Glynn EL; Center for Metabolic Health, University of Texas Medical Branch, Galveston, Texas, United States., Markofski MM; Sealy Center on Aging, University of Texas Medical Branch, Galveston, Texas, United States., Timmerman KL; Department of Internal Medicine/Geriatrics, University of Texas Medical Branch, Galveston, Texas, United States., Moro T; Sealy Center on Aging, University of Texas Medical Branch, Galveston, Texas, United States., Volpi E; Sealy Center on Aging, University of Texas Medical Branch, Galveston, Texas, United States.; Department of Internal Medicine/Geriatrics, University of Texas Medical Branch, Galveston, Texas, United States., Trappe S; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Trappe TA; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Harber MP; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Rasmussen BB; Center for Metabolic Health, University of Texas Medical Branch, Galveston, Texas, United States.; Sealy Center on Aging, University of Texas Medical Branch, Galveston, Texas, United States.; Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States.
Jazyk:	angličtina
Zdroj:	American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2023 Aug 01; Vol. 325 (2), pp. E113-E118. Date of Electronic Publication: 2023 Jun 14.
DOI:	10.1152/ajpendo.00144.2023
Abstrakt:	Several factors affect muscle protein synthesis (MPS) in the postabsorptive state. Extreme physical inactivity (e.g., bedrest) may reduce basal MPS, whereas walking may augment basal MPS. We hypothesized that outpatients would have a higher postabsorptive MPS than inpatients. To test this hypothesis, we conducted a retrospective analysis. We compared 152 outpatient participants who arrived at the research site the morning of the MPS assessment with 350 Inpatient participants who had an overnight stay in the hospital unit before the MPS assessment the following morning. We used stable isotopic methods and collected vastus lateralis biopsies ∼2 to 3 h apart to assess mixed MPS. MPS was ∼12% higher ( P < 0.05) for outpatients than inpatients. Within a subset of participants, we discovered that after instruction to limit activity, outpatients ( n = 13) took 800 to 900 steps in the morning to arrive at the unit, seven times more steps than inpatients ( n = 12). We concluded that an overnight stay in the hospital as an inpatient is characterized by reduced morning activity and causes a slight but significant reduction in MPS compared with participants studied as outpatients. Researchers should be aware of physical activity status when designing and interpreting MPS results. NEW & NOTEWORTHY The postabsorptive muscle protein synthesis rate is lower in the morning after an overnight inpatient hospital stay compared with an outpatient visit. Although only a minimal amount of steps was conducted by outpatients (∼900), this was enough to increase postabsorptive muscle protein synthesis rate.
Databáze:	MEDLINE
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