Significance of EGFR investigation in odontogenic keratocyst: a narrative review.

Autor: Vasiljevic V; Public Health Hospital, 'Sveti Apostol Luka', Doboj, Bosnia and Herzegovina., Obradovic J; Department of Sciences, Institute for Information Technologies Kragujevac, University of Kragujevac, 34000, Kragujevac, Republic of Serbia., Jurisic V; Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića 69, 34000, Kragujevac, Republic of Serbia. jurisicvladimir@gmail.com.
Jazyk: angličtina
Zdroj: Molecular biology reports [Mol Biol Rep] 2023 Aug; Vol. 50 (8), pp. 7089-7098. Date of Electronic Publication: 2023 Jun 14.
DOI: 10.1007/s11033-023-08582-3
Abstrakt: Background: The recent classification of odontogenic keratocysts (OKSs) recognized them as benign neoplasms, although previous findings have revealed their aggressive nature. Immunohistochemical and molecular analyses have investigated OKSs, but the role of epidermal growth factor receptor (EGFR) has not been fully investigated, despite the importance of this oncogene in the process of carcinogenesis in tumors of epithelial origin. The EGFR protein is usually overexpressed, and the EGFR gene is mutated or amplified.
Aims of Study: This brief review aims to emphasize the importance of EGFR detection in these types of cysts.
Methods and Results: It was revealed that the majority of the studies examined EGFR protein expression using immunohistochemical methods; however, considering EGFR gene variants, mutations were less explored in the previous period from 1992 to 2023. Although EGFR gene polymorphisms are clinically important, they were not identified in the present study.
Conclusions: In light of the current significance of EGFR variants, it would be beneficial to examine them in odontogenic lesions. This would enable resolving of discrepancies about their nature, and potentially enhance classifications OKCs in the future.
(© 2023. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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