Maternal anxiety-driven modulation of fetal limbic connectivity designs a backbone linking neonatal brain functional topology to socio-emotional development in early childhood.

Autor: Canini M; Department of Neuroradiology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Pecco N; Department of Neuroradiology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Caglioni M; Department of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Katušić A; Croatian Institute for Brain Research, University of Zagreb, School of Medicine, Zagreb, Croatia., Išasegi IŽ; Croatian Institute for Brain Research, University of Zagreb, School of Medicine, Zagreb, Croatia.; Department of Child and Adolescent Psychiatry, Clinical Hospital Centre Zagreb, Zagreb, Croatia., Oprandi C; Department of Neuroradiology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Scifo P; Department of Nuclear Medicine, IRCCS San Raffaele Scientific Institute, Milan, Italy., Pozzoni M; Department of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Lorioli L; Department of Neonatology, ASST Papa Giovanni XXIII, Bergamo, Italy., Garbetta G; Mother-Child Department: Neonatology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Poloniato A; Mother-Child Department: Neonatology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Sora MGN; Department of Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Cavoretto PI; Department of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Barera G; Mother-Child Department: Neonatology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Candiani M; Department of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Kostović I; Croatian Institute for Brain Research, University of Zagreb, School of Medicine, Zagreb, Croatia., Falini A; Department of Neuroradiology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Baldoli C; Department of Neuroradiology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Della Rosa PA; Department of Neuroradiology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Jazyk: angličtina
Zdroj: Journal of neuroscience research [J Neurosci Res] 2023 Sep; Vol. 101 (9), pp. 1484-1503. Date of Electronic Publication: 2023 Jun 14.
DOI: 10.1002/jnr.25207
Abstrakt: A link between maternal anxiety during pregnancy and adverse socio-emotional outcomes in childhood has been consistently sustained on the very early neurodevelopmental alteration of structural pathways between fetal limbic and cortical brain regions. In this study, we provide follow-up evidence for a feed-forward model linking (i) maternal anxiety, (ii) fetal functional neurodevelopment, (iii) neonatal functional network organization with (iv) socio-emotional neurobehavioral development in early childhood. Namely, we investigate a sample of 16 mother-fetus dyads and show how a maternal state-trait anxiety profile with pregnancy-specific worries can significantly influence functional synchronization patterns between regions of the fetal limbic system (i.e., hippocampus and amygdala) and the neocortex, as assessed through resting-state functional magnetic resonance imaging. Generalization of the findings was supported by leave-one-out cross-validation. We further show how this maternal-fetal cross-talk propagates to functional network topology in the neonate, specifically targeting connector hubs, and further maps onto socio-emotional profiles, assessed through Bayley-III socio-emotional scale in early childhood (i.e., in the 12-24 months range). Based on this evidence, we put forward the hypothesis of a "Maternal-Fetal-Neonatal Anxiety Backbone", through which neurobiological changes driven by maternal anxiety could trigger a divergence in the establishment of a cognitive-emotional development blueprint, in terms of the nascent functional homeostasis between bottom-up limbic and top-down higher-order neuronal circuitry.
(© 2023 The Authors. Journal of Neuroscience Research published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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