Pola-R-CHP for frontline therapy in DLBCL: Are we saving money by spending more?

Autor: Vitolo U; Medical Oncology, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Frascione PMM; Medical Oncology, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Bonello F; Medical Oncology, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.
Jazyk: angličtina
Zdroj: British journal of haematology [Br J Haematol] 2023 Aug; Vol. 202 (4), pp. 731-733. Date of Electronic Publication: 2023 Jun 14.
DOI: 10.1111/bjh.18934
Abstrakt: The study by Kambhampati et al. offers the first European perspective on cost-effectiveness of pola-R-CHP in the frontline line treatment of DLBCL patients. Nevertheless, the applicability of these results in other European settings remain questionable: Germany is indeed a wealthy country with wide access to cellular therapies in earlier lines, while this might not be the case for other European countries. The presented data must be re-assessed when long term data on PFS and OS from the POLARIX trial are available, ideally considering also real-life data. Similar CEAs in other European health care systems as well as in specific subgroups of patients are welcome to offer a broader perspective on the potential role of pola-R-CHP in Europe. Commentary on: Kambhampati et al. Cost effectiveness of polatuzumab vedotin in combination with chemoimmunotherapy (pola-R-CHP) in previously untreated diffuse large B-cell lymphoma in Germany. Br J Haematol 2023;202:771-775.
(© 2023 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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