Natural and natural-like polyphenol compounds: in vitro antioxidant activity and potential for therapeutic application.

Autor:	Brboric J; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Serbia, Serbia., Klisic A; Primary Health Care Center, University of Montenegro, Faculty of Medicine, Podgorica, Montenegro, Montenegro., Kotur-Stevuljevic J; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Serbia, Serbia., Delogu G; CNR - Institute of Biomolecular Chemistry, Sassari, Italy, Italy., Gjorgieva Ackova D; Faculty of Medical Sciences, Goce Delcev University, Stip, Republic of North Macedonia, North Macedonia., Kostic K; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Serbia, Serbia., Antonietta Dettori M; CNR - Institute of Biomolecular Chemistry, Sassari, Italy, Italy., Fabbri D; CNR - Institute of Biomolecular Chemistry, Sassari, Italy, Italy., Carta P; CNR - Institute of Biomolecular Chemistry, Sassari, Italy, Italy., Saso L; Department of Physiology and Pharmacology 'Vittorio Erspamer', Sapienza University of Rome, Italy, Italy.
Jazyk:	angličtina
Zdroj:	Archives of medical science : AMS [Arch Med Sci] 2021 Apr 18; Vol. 19 (3), pp. 651-671. Date of Electronic Publication: 2021 Apr 18 (Print Publication: 2023).
DOI:	10.5114/aoms/135379
Abstrakt:	Introduction: Phenols are a large family of natural and synthetic compounds with known antioxidant activity. The aim of this study was to perform in vitro screening of natural and natural-like phenol monomers and their C2-symmetric dimers (hydroxylated biphenyls) in order to identify those representatives whose pharmacophores have the strongest antioxidant and the lowest prooxidant activity. Material and Methods: Antioxidative properties of 36 compounds (monomers and their C2-symmetric dimers) were evaluated in vitro . Different (red/ox) assays were used to measure their total oxidative potential (TOP), their total antioxidative capacity (TAC), the pro-oxidative-antioxidant balance (PAB) and total SH-group content (SHG) in a biologically relevant environment. The Pro-oxidative Score, Antioxidative Score and the Oxy Score were also calculated. Trolox, a water soluble analogue of α-tocopherol, was used as a positive control. Results: In an assay consisting of pooled human serum, 6 of the 36 compounds showed significant antioxidant activity (compounds 6, 7, 12, 13, 26, and 27), whereas 4 showed extremely weak antioxidant activity (compounds 2, 29, 30, and 31). Within the 36 compounds comprising zingerone, dehydrozingerone, aurone, chalcone, and magnolol derivatives, in both monomeric and dimeric forms, the 2 compounds that indicated the highest antioxidant activity were dehydrozingerone derivatives (compounds 6 and 12). Trolox's activity was found between the strong and weak antioxidant compounds analysed in our study. Conclusions: In this study selected dehydrozingerones were identified as good candidates for in-depth testing of their biological behaviour and for possible precursors for synthesis of novel polyphenolic molecules with potential therapeutic applications. Competing Interests: The authors declare no conflict of interest. (Copyright: © 2021 Termedia & Banach.)
Databáze:	MEDLINE
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