Comparison of acute phase response in mice after inhalation and intratracheal instillation of molybdenum disulphide and tungsten particles.

Autor: Gutierrez CT; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.; National Research Centre for the Working Environment, Copenhagen, Denmark., Loizides C; Climate and Atmosphere Research Centre, The Cyprus Institute, Nicosia, Cyprus., Hafez I; Climate and Atmosphere Research Centre, The Cyprus Institute, Nicosia, Cyprus., Biskos G; Climate and Atmosphere Research Centre, The Cyprus Institute, Nicosia, Cyprus.; Faculty of Civil Engineering and Geosciences, Delft University of Technology, Delft, The Netherlands., Loeschner K; Research Group for Analytical Food Chemistry, National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark., Brostrøm A; National Research Centre for the Working Environment, Copenhagen, Denmark., Roursgaard M; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Saber AT; National Research Centre for the Working Environment, Copenhagen, Denmark., Møller P; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Sørli JB; National Research Centre for the Working Environment, Copenhagen, Denmark., Hadrup N; National Research Centre for the Working Environment, Copenhagen, Denmark.; Research Group for Risk-Benefit, National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark., Vogel U; National Research Centre for the Working Environment, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2023 Sep; Vol. 133 (3), pp. 265-278. Date of Electronic Publication: 2023 Jul 03.
DOI: 10.1111/bcpt.13915
Abstrakt: Inhalation studies are the gold standard for assessing the toxicity of airborne materials. They require considerable time, special equipment, and large amounts of test material. Intratracheal instillation is considered a screening and hazard assessment tool as it is simple, quick, allows control of the applied dose, and requires less test material. The particle-induced pulmonary inflammation and acute phase response in mice caused by intratracheal instillation or inhalation of molybdenum disulphide or tungsten particles were compared. End points included neutrophil numbers in bronchoalveolar lavage fluid, Saa3 mRNA levels in lung tissue and Saa1 mRNA levels in liver tissue, and SAA3 plasma protein. Acute phase response was used as a biomarker for the risk of cardiovascular disease. Intratracheal instillation of molybdenum disulphide or tungsten particles did not produce pulmonary inflammation, while molybdenum disulphide particles induced pulmonary acute phase response with both exposure methods and systemic acute phase response after intratracheal instillation. Inhalation and intratracheal instillation showed similar dose-response relationships for pulmonary and systemic acute phase response when molybdenum disulphide was expressed as dosed surface area. Both exposure methods showed similar responses for molybdenum disulphide and tungsten, suggesting that intratracheal instillation can be used for screening particle-induced acute phase response and thereby particle-induced cardiovascular disease.
(© 2023 The Authors. Basic & Clinical Pharmacology & Toxicology published by John Wiley & Sons Ltd on behalf of Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).)
Databáze: MEDLINE
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