Prevalence and significance of extracardiac uptake on pyrophosphate imaging in the SCAN-MP study: the first 379 cases.

Autor: Chan N; Seymour, Paul and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA.; Clinical Cardiovascular Research Laboratory for the Elderly, 21 Audubon Avenue, New York, NY, 10032, USA., Einstein AJ; Seymour, Paul and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA.; Department of Radiology, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, NY, USA., Griffin JM; Division of Cardiology, Medical University of South Carolina, Charleston, SC, USA., Rosenblum H; Seymour, Paul and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA., Teruya S; Seymour, Paul and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA.; Clinical Cardiovascular Research Laboratory for the Elderly, 21 Audubon Avenue, New York, NY, 10032, USA., Cuomo M; Seymour, Paul and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA.; Clinical Cardiovascular Research Laboratory for the Elderly, 21 Audubon Avenue, New York, NY, 10032, USA., De Los Santos J; Seymour, Paul and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA.; Clinical Cardiovascular Research Laboratory for the Elderly, 21 Audubon Avenue, New York, NY, 10032, USA., DeLuca A; Seymour, Paul and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA., Johnson LL; Seymour, Paul and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA., Kinkhabwala MP; Seymour, Paul and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA., Leb JS; Department of Radiology, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, NY, USA., Mintz A; Department of Radiology, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, NY, USA., Fine D; Section of Cardiovascular Medicine, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, MA, USA., Helmke S; Seymour, Paul and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA.; Clinical Cardiovascular Research Laboratory for the Elderly, 21 Audubon Avenue, New York, NY, 10032, USA., Muralidhar V; Section of Cardiovascular Medicine, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, MA, USA., Pandey S; Section of Cardiovascular Medicine, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, MA, USA., Sabogal N; Section of Cardiovascular Medicine, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, MA, USA., Saith SE; Division of Cardiovascular Medicine, Department of Medicine, SUNY Downstate College of Medicine, Brooklyn, NY, USA., Winburn M; Section of Cardiovascular Medicine, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, MA, USA., Smiley D; Seymour, Paul and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA., Miller EJ; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA., Ruberg FL; Section of Cardiovascular Medicine, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, MA, USA., Maurer MS; Seymour, Paul and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA. msm10@cumc.columbia.edu.; Clinical Cardiovascular Research Laboratory for the Elderly, 21 Audubon Avenue, New York, NY, 10032, USA. msm10@cumc.columbia.edu.
Jazyk: angličtina
Zdroj: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology [J Nucl Cardiol] 2023 Dec; Vol. 30 (6), pp. 2531-2539. Date of Electronic Publication: 2023 Jun 13.
DOI: 10.1007/s12350-023-03310-7
Abstrakt: Introduction: Technetium-labeled bone-avid radiotracers can be used to diagnose transthyretin cardiac amyloidosis (ATTR-CA). Extracardiac uptake of technetium pyrophosphate (Tc-99m PYP) in this context has not been extensively explored and its significance is not well characterized. We assessed extracardiac Tc-99m PYP uptake in individuals undergoing nuclear scintigraphy and the extent of clinically actionable findings.
Methods: The Screening for Cardiac Amyloidosis with Nuclear Imaging in Minority Populations (SCAN-MP) study utilizes Tc-99m PYP imaging to identify ATTR-CA in self-identified Black and Caribbean Hispanic participants ≥ 60 years old with heart failure. We characterized the distribution of extracardiac uptake, including stratification of findings by timing of scan (1 hour vs 3 hours after Tc-99m PYP administration) and noted any additional testing in these subjects.
Results: Of 379 participants, 195 (51%) were male, 306 (81%) Black race, and 120 (32%) Hispanic ethnicity; mean age was 73 years. Extracardiac Tc-99m PYP uptake was found in 42 subjects (11.1%): 21 with renal uptake only, 14 with bone uptake only, 4 with both renal and bone uptake, 2 with breast uptake, and 1 with thyroid uptake. Extracardiac uptake was more common in subjects with Tc-99m PYP scans at 1 hour (23.8%) than at 3 hours (6.2%). Overall, four individuals (1.1%) had clinically actionable findings.
Conclusion: Extracardiac Tc-99m PYP uptake manifested in about 1 in 9 SCAN-MP subjects but was clinically actionable in only 1.1% of cases.
(© 2023. The Author(s) under exclusive licence to American Society of Nuclear Cardiology.)
Databáze: MEDLINE
Externí odkaz: