Reduction of estimated glomerular filtration rate after COVID-19-associated acute kidney injury.

Autor: Bento GAO; Centro Universitário Tiradentes, Faculdade de Medicina, Maceió, AL, Brazil., Leite VLT; Centro Universitário Tiradentes, Faculdade de Medicina, Maceió, AL, Brazil., Campos RP; Universidade Federal de Alagoas, Faculdade de Medicina, Maceió, AL, Brazil.; Centro Universitário CESMAC, Faculdade de Medicina, Maceió, AL, Brazil., Vaz FB; Centro Universitário CESMAC, Faculdade de Medicina, Maceió, AL, Brazil., Daher EF; Universidade Federal do Ceará, Faculdade de Medicina, Fortaleza, CE, Brazil., Duarte DB; Centro Universitário Tiradentes, Faculdade de Medicina, Maceió, AL, Brazil.; Universidade Federal de Alagoas, Faculdade de Medicina, Maceió, AL, Brazil.; Centro Universitário CESMAC, Faculdade de Medicina, Maceió, AL, Brazil.; Universidade Federal do Ceará, Faculdade de Medicina, Fortaleza, CE, Brazil.
Jazyk: English; Portuguese
Zdroj: Jornal brasileiro de nefrologia [J Bras Nefrol] 2023 Oct-Dec; Vol. 45 (4), pp. 488-494.
DOI: 10.1590/2175-8239-JBN-2022-0179en
Abstrakt: Introduction: Acute Kidney Injury (AKI), a frequent manifestation in COVID-19, can compromise kidney function in the long term. We evaluated renal function after hospital discharge of patients who developed AKI associated with COVID-19.
Methods: This is an ambidirectional cohort. eGFR and microalbuminuria were reassessed after hospital discharge (T1) in patients who developed AKI due to COVID-19, comparing the values with hospitalization data (T0). P < 0.05 was considered statistically significant.
Results: After an average of 16.3 ± 3.5 months, 20 patients were reassessed. There was a median reduction of 11.5 (IQR: -21; -2.1) mL/min/1.73m2 per year in eGFR. Forty-five percent of patients had CKD at T1, were older, and had been hospitalized longer; this correlated negatively with eGFR at T1. Microalbuminuria was positively correlated with CRP at T0 and with a drop in eGFR, as well as eGFR at admission with eGFR at T1.
Conclusion: There was a significant reduction in eGFR after AKI due to COVID-19, being associated with age, length of hospital stay, CRP, and need for hemodialysis.
Databáze: MEDLINE
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