Relationship between anthropometric and body composition parameters and anti-SARS-CoV-2 specific IgG titers in females vaccinated against COVID-19 according to the heterologous vaccination course: A cohort study.

Autor: Golec M; Silesian Park of Medical Technology Kardio-Med Silesia, Zabrze, Poland., Zembala-John J; Silesian Park of Medical Technology Kardio-Med Silesia, Zabrze, Poland.; Department of Medicine and Environmental Epidemiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland.; Silesian Center for Heart Diseases, Zabrze, Poland., Fronczek M; Silesian Park of Medical Technology Kardio-Med Silesia, Zabrze, Poland.; Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland., Konka A; Silesian Park of Medical Technology Kardio-Med Silesia, Zabrze, Poland., Bochenek A; Silesian Park of Medical Technology Kardio-Med Silesia, Zabrze, Poland., Wystyrk K; Silesian Park of Medical Technology Kardio-Med Silesia, Zabrze, Poland., Botor H; Acellmed Ltd., Zabrze, Poland., Zalewska M; Silesian Park of Medical Technology Kardio-Med Silesia, Zabrze, Poland.; Department of Basic Medical Sciences, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, Bytom, Poland., Chrapiec M; Silesian Park of Medical Technology Kardio-Med Silesia, Zabrze, Poland., Kasperczyk S; Department of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland., Brzoza Z; Department of Internal Diseases, Allergology, Endocrinology and Gastroenterology, Institute of Medical Sciences, University of Opole, Opole, Poland., Bułdak RJ; Silesian Park of Medical Technology Kardio-Med Silesia, Zabrze, Poland.; Department of Clinical Biochemistry and Laboratory Diagnostics, Institute of Medical Sciences, University of Opole, Opole, Poland.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Jun 13; Vol. 18 (6), pp. e0287128. Date of Electronic Publication: 2023 Jun 13 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0287128
Abstrakt: Introduction: The aim of this cohort study was to evaluate the relationship between anthropometric and body composition parameters and anti-SARS-CoV-2 IgG titers in a group of females who were vaccinated against COVID-19 with two doses of ChAdOx1 vaccine and then boosted with the BNT162b2 vaccine.
Materials and Methods: The study group consisted of 63 women. Basic demographic and clinical data were collected. To assess the anti-SARS-CoV-2 immunoglobulin G titers following the vaccination, five blood draws were performed: 1) before the first dose, 2) before the second dose, 3) 14-21 days after the primary vaccination, 4) before the booster, and 5) 21 days after the booster. Blood samples were analyzed using a two-step enzymatic chemiluminescent assay. Body mass index and body composition were evaluated using bioelectrical impedance analysis. To select the most distinguishing parameters and correlations between anthropometric and body composition parameters and anti-SARS-CoV-2 IgG titers, factor analysis using the Principal Component Analysis was conducted.
Results: Sixty-three females (mean age: 46.52 years) who met the inclusion criteria were enrolled. 40 of them (63.50%) participated in the post-booster follow-up. After receiving two doses of the ChAdOx1 vaccine, the study group's anti-SARS-CoV-2 IgG titers were 67.19 ± 77.44 AU/mL (mean ± SD), whereas after receiving a heterologous mRNA booster, the level of anti-SARS-CoV-2 IgG titers was about three-times higher and amounted to 212.64 ± 146.40 AU/mL (mean ± SD). Our data shows that seropositivity, obesity, non-fat-related, and fat-related body composition parameters all had a significant effect on the level of IgG titer after a two-dose vaccination of ChAdOx1. However, only non-fat-related and fat-related body composition parameters had a significant effect on the IgG titer after booster vaccination.
Conclusion: COVID-19 infection before the first dose of vaccination is not related to IgG titer after booster administration. Body composition has a significant effect on the production of anti-SARS-CoV-2 IgG after booster vaccination in females.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Golec et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje