Green polymer altered in-situ gel oral liquid sustainable release preparation of vildagliptin suitable for dysphagic diabetic patients: assessment in-vitro & in-vivo .

Autor: El-Masry SM; Department of Pharmaceutics, Damanhour University, Damanhour, Egypt., ElBedaiwy HM; Department of Pharmaceutics, Damanhour University, Damanhour, Egypt., Abd-Alhaseeb MM; Department of Pharmacology & Toxicology, Damanhour University, Damanhour, Egypt., Abdel-Maksoud MS; Department of Pharmacology & Toxicology, University of Tabuk, Tabuk, Saudi Arabia., Habib DA; Department of Pharmaceutics, Damanhour University, Damanhour, Egypt.
Jazyk: angličtina
Zdroj: Pharmaceutical development and technology [Pharm Dev Technol] 2023 Sep; Vol. 28 (7), pp. 585-594. Date of Electronic Publication: 2023 Jun 21.
DOI: 10.1080/10837450.2023.2223293
Abstrakt: Purpose: This work aimed to fabricate alginate based in-situ gelling matrix of vildagliptin improved by calcium and carboxy methyl cellulose (CMC) for appropriate adjustment of the onset and duration of action. This easy-to-swallow thickened liquid preparation aimed to improve compliance for dysphagic or elderly diabetic patients.
Methods: Vildagliptin dispersions containing alginate were fabricated in the presence or absence of calcium chloride to assess the effect of calcium ion, then a matrix containing 1.5% w/v of sodium alginate with calcium was further examined after the addition of CMC with different concentrations ranging from 0.1% to 0.3%. The viscosity, gelling forming property, Differential scanning calorimetry, and in-vitro drug release were assessed before monitoring the hypoglycemic effect of the selected formulation.
Results: In-situ gel matrixes were fabricated at gastric pH with and without calcium ions. The best formula concerning viscosity and the gel-forming property was achieved with higher CMC concentrations, which in turn decreased the rate of vildagliptin release in stimulated gastric pH. In-vivo results confirmed the extended hypoglycemic effect of the vildagliptin in-situ gelling matrix compared to the vildagliptin aqueous solution.
Conclusion: This study represents a green polymeric-based in-situ gel as a liquid oral retarded release preparation intended for reducing dose frequency, easier administration of vildagliptin, and improving compliance in geriatric and dysphagic diabetic patients.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje