Null results of oxytocin and vasopressin administration on mentalizing in a large fMRI sample: evidence from a randomized controlled trial.

Autor:	Straccia MA; Department of Psychology, University of California, Los Angeles, CA, USA., Teed AR; Department of Psychology, Southern Methodist University, Dallas, TX, USA., Katzman PL; Department of Psychology, New York University, New York, NY, USA., Tan KM; Department of Psychology, University of California, Los Angeles, CA, USA., Parrish MH; Department of Psychology, University of California, Los Angeles, CA, USA., Irwin MR; Department of Psychology, University of California, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Cousins Center for Psychoneuroimmunology, Jane and Terry Semel Institute for Neuroscience, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Eisenberger NI; Department of Psychology, University of California, Los Angeles, CA, USA., Lieberman MD; Department of Psychology, University of California, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Tabak BA; Department of Psychology, Southern Methodist University, Dallas, TX, USA.
Jazyk:	angličtina
Zdroj:	Psychological medicine [Psychol Med] 2023 Apr; Vol. 53 (6), pp. 2285-2295. Date of Electronic Publication: 2021 Oct 15.
DOI:	10.1017/S0033291721004104
Abstrakt:	Background: Although potential links between oxytocin (OT), vasopressin (AVP), and social cognition are well-grounded theoretically, most studies have included all male samples, and few have demonstrated consistent effects of either neuropeptide on mentalizing (i.e. understanding the mental states of others). To understand the potential of either neuropeptide as a pharmacological treatment for individuals with impairments in social cognition, it is important to demonstrate the beneficial effects of OT and AVP on mentalizing in healthy individuals. Methods: In the present randomized, double-blind, placebo-controlled study ( n = 186) of healthy individuals, we examined the effects of OT and AVP administration on behavioral responses and neural activity in response to a mentalizing task. Results: Relative to placebo, neither drug showed an effect on task reaction time or accuracy, nor on whole-brain neural activation or functional connectivity observed within brain networks associated with mentalizing. Exploratory analyses included several variables previously shown to moderate OT's effects on social processes (e.g., self-reported empathy, alexithymia) but resulted in no significant interaction effects. Conclusions: Results add to a growing literature demonstrating that intranasal administration of OT and AVP may have a more limited effect on social cognition, at both the behavioral and neural level, than initially assumed. Randomized controlled trial registrations: ClinicalTrials.gov; NCT02393443; NCT02393456; NCT02394054.
Databáze:	MEDLINE
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