From MEG to clinical EEG: evaluating a promising non-invasive estimator of defense-related muscle sympathetic nerve inhibition.

Autor: Eskelin JJ; Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy at University of Gothenburg, 413 45, Gothenburg, Sweden. john.jonsson.eskelin@gu.se., Lundblad LC; Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy at University of Gothenburg, 413 45, Gothenburg, Sweden.; Department of Clinical Neurophysiology, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden., Wallin BG; Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy at University of Gothenburg, 413 45, Gothenburg, Sweden., Karlsson T; Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy at University of Gothenburg, 413 45, Gothenburg, Sweden., Riaz B; Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy at University of Gothenburg, 413 45, Gothenburg, Sweden., Lundqvist D; NatMEG, Department of Clinical Neuroscience, Karolinska Institutet, 171 77, Stockholm, Sweden., Schneiderman JF; Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy at University of Gothenburg, 413 45, Gothenburg, Sweden.; Department of Clinical Neurophysiology, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden., Elam M; Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy at University of Gothenburg, 413 45, Gothenburg, Sweden.; Department of Clinical Neurophysiology, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Jun 12; Vol. 13 (1), pp. 9507. Date of Electronic Publication: 2023 Jun 12.
DOI: 10.1038/s41598-023-36753-6
Abstrakt: Sudden, unexpected stimuli can induce a transient inhibition of sympathetic vasoconstriction to skeletal muscle, indicating a link to defense reactions. This phenomenon is relatively stable within, but differs between, individuals. It correlates with blood pressure reactivity which is associated with cardiovascular risk. Inhibition of muscle sympathetic nerve activity (MSNA) is currently characterized through invasive microneurography in peripheral nerves. We recently reported that brain neural oscillatory power in the beta spectrum (beta rebound) recorded with magnetoencephalography (MEG) correlated closely with stimulus-induced MSNA inhibition. Aiming for a clinically more available surrogate variable reflecting MSNA inhibition, we investigated whether a similar approach with electroencephalography (EEG) can accurately gauge stimulus-induced beta rebound. We found that beta rebound shows similar tendencies to correlate with MSNA inhibition, but these EEG data lack the robustness of previous MEG results, although a correlation in the low beta band (13-20 Hz) to MSNA inhibition was found (p = 0.021). The predictive power is summarized in a receiver-operating-characteristics curve. The optimum threshold yielded sensitivity and false-positive rate of 0.74 and 0.33 respectively. A plausible confounder is myogenic noise. A more complicated experimental and/or analysis approach is required for differentiating MSNA-inhibitors from non-inhibitors based on EEG, as compared to MEG.
(© 2023. The Author(s).)
Databáze: MEDLINE
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