Whole-genome sequencing rule-out of suspected hospital-onset Rhizopus outbreaks.

Autor: Chu VT; Division of Infectious Diseases and Global Health, Department of Pediatrics, University of California-San Francisco, San Francisco, California., Nafees S; Chan Zuckerberg Biohub, San Francisco, California., Waltari E; Chan Zuckerberg Biohub, San Francisco, California., McNeil N; Department of Hospital Epidemiology and Infection Prevention, University of California-San Francisco, San Francisco, California., Caughell C; Department of Hospital Epidemiology and Infection Prevention, University of California-San Francisco, San Francisco, California., Sanchez-Guerrero E; Division of Infectious Diseases, Department of Medicine, University of California-San Francisco, San Francisco, California., Wang L; Department of Hospital Epidemiology and Infection Prevention, University of California-San Francisco, San Francisco, California., Stanley K; Department of Hospital Epidemiology and Infection Prevention, University of California-San Francisco, San Francisco, California., Cunningham G; Department of Laboratory Medicine, University of California-San Francisco, San Francisco, California., Wong J; Chan Zuckerberg Biohub, San Francisco, California., Phelps M; Chan Zuckerberg Biohub, San Francisco, California., Tato CM; Chan Zuckerberg Biohub, San Francisco, California., Miller S; Illumina, Inc, Foster City, California., DeRisi JL; Chan Zuckerberg Biohub, San Francisco, California.; Department of Biochemistry and Biophysics, University of California-San Francisco, San Francisco, California., Yokoe DS; Department of Hospital Epidemiology and Infection Prevention, University of California-San Francisco, San Francisco, California.; Division of Infectious Diseases, Department of Medicine, University of California-San Francisco, San Francisco, California., Ramirez-Avila L; Division of Infectious Diseases and Global Health, Department of Pediatrics, University of California-San Francisco, San Francisco, California.; Department of Hospital Epidemiology and Infection Prevention, University of California-San Francisco, San Francisco, California., Langelier CR; Chan Zuckerberg Biohub, San Francisco, California.; Department of Hospital Epidemiology and Infection Prevention, University of California-San Francisco, San Francisco, California.; Division of Infectious Diseases, Department of Medicine, University of California-San Francisco, San Francisco, California.
Jazyk: angličtina
Zdroj: Infection control and hospital epidemiology [Infect Control Hosp Epidemiol] 2023 Dec; Vol. 44 (12), pp. 2059-2061. Date of Electronic Publication: 2023 Jun 13.
DOI: 10.1017/ice.2023.85
Abstrakt: Two independent temporal-spatial clusters of hospital-onset Rhizopus infections were evaluated using whole-genome sequencing (WGS). Phylogenetic analysis confirmed that isolates within each cluster were unrelated despite epidemiological suspicion of outbreaks. The ITS1 region alone was insufficient for accurate analysis. WGS has utility for rapid rule-out of suspected nosocomial Rhizopus outbreaks.
Databáze: MEDLINE