Exercise alters cortico-basal ganglia network metabolic connectivity: a mesoscopic level analysis informed by anatomic parcellation defined in the mouse brain connectome.

Autor: Wang Z; Department of Psychiatry and Behavioral Sciences, University of Southern California, 1975 Zonal Avenue, KAM 400, MC9037, Los Angeles, California, 90089-9037, USA., Donahue EK; Graduate Program in Neurosciences, University of Southern California, Los Angeles, California, USA., Guo Y; Department of Psychiatry and Behavioral Sciences, University of Southern California, 1975 Zonal Avenue, KAM 400, MC9037, Los Angeles, California, 90089-9037, USA., Renteln M; Department of Neurology, University of Southern California, Los Angeles, California, USA., Petzinger GM; Graduate Program in Neurosciences, University of Southern California, Los Angeles, California, USA.; Department of Neurology, University of Southern California, Los Angeles, California, USA., Jakowec MW; Graduate Program in Neurosciences, University of Southern California, Los Angeles, California, USA.; Department of Neurology, University of Southern California, Los Angeles, California, USA., Holschneider DP; Department of Psychiatry and Behavioral Sciences, University of Southern California, 1975 Zonal Avenue, KAM 400, MC9037, Los Angeles, California, 90089-9037, USA. holschne@usc.edu.; Graduate Program in Neurosciences, University of Southern California, Los Angeles, California, USA. holschne@usc.edu.; Department of Neurology, University of Southern California, Los Angeles, California, USA. holschne@usc.edu.; Department of Biomedical Engineering, University of Southern California, Los Angeles, California, USA. holschne@usc.edu.
Jazyk: angličtina
Zdroj: Brain structure & function [Brain Struct Funct] 2023 Nov; Vol. 228 (8), pp. 1865-1884. Date of Electronic Publication: 2023 Jun 12.
DOI: 10.1007/s00429-023-02659-2
Abstrakt: The basal ganglia are important modulators of the cognitive and motor benefits of exercise. However, the neural networks underlying these benefits remain poorly understood. Our study systematically analyzed exercise-associated changes in metabolic connectivity in the cortico-basal ganglia-thalamic network during the performance of a new motor task, with regions-of-interest defined based on mesoscopic domains recently defined in the mouse brain structural connectome. Mice were trained on a motorized treadmill for six weeks or remained sedentary (control), thereafter undergoing [ 14 C]-2-deoxyglucose metabolic brain mapping during wheel walking. Regional cerebral glucose uptake (rCGU) was analyzed in 3-dimensional brains reconstructed from autoradiographic brain sections using statistical parametric mapping. Metabolic connectivity was assessed by calculating inter-regional correlation of rCGU cross-sectionally across subjects within a group. Compared to controls, exercised animals showed broad decreases in rCGU in motor areas, but increases in limbic areas, as well as the visual and association cortices. In addition, exercised animals showed (i) increased positive metabolic connectivity within and between the motor cortex and caudoputamen (CP), (ii) newly emerged negative connectivity of the substantia nigra pars reticulata with the globus pallidus externus, and CP, and (iii) reduced connectivity of the prefrontal cortex (PFC). Increased metabolic connectivity in the motor circuit in the absence of increases in rCGU strongly suggests greater network efficiency, which is also supported by the reduced involvement of PFC-mediated cognitive control during the performance of a new motor task. Our study delineates exercise-associated changes in functional circuitry at the subregional level and provides a framework for understanding the effects of exercise on functions of the cortico-basal ganglia-thalamic network.
(© 2023. The Author(s).)
Databáze: MEDLINE
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