Association between interleukin-27 gene polymorphisms and Plasmodium falciparum Malaria.

Autor: Aljarba NH; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., Al-Anazi MR; Department of Infection and Immunity, Research Centre, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia., Al-Hazani TM; Department of Biology, College of Science and Humanities, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia., Shafeai MI; Sabya General Hospital, Sabya, Saudi Arabia., Rudiny FH; Sabya General Hospital, Sabya, Saudi Arabia., Motaen AM; Sabya General Hospital, Sabya, Saudi Arabia., Bin Dajem SM; Department of Biology, College of Science, King Khalid University, Abha, Saudi Arabia., Alothaid H; Department of Basic Sciences, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Saudi Arabia., Alghamdi J; The Saudi Biobank, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia., Alkahtani S; Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia., Al-Qahtani AA; Department of Infection and Immunity, Research Centre, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.; Department of Microbiology and Immunology, Alfaisal University, School of Medicine, Riyadh, Saudi Arabia.
Jazyk: angličtina
Zdroj: Innate immunity [Innate Immun] 2023 Jul; Vol. 29 (5), pp. 83-94. Date of Electronic Publication: 2023 Jun 12.
DOI: 10.1177/17534259231178594
Abstrakt: Malaria is often characterized by a complicated disease course due to multifaceted intrinsic genetic factors of the host and the parasite. This study aimed to investigate the role of interleukin-27 ( IL-27 ) gene polymorphisms in Plasmodium falciparum malaria infection in a Saudi Arabian cohort. This case-control study obtained blood samples from 250 malaria patients with P. falciparum and 200 randomly identified healthy control subjects from the Malaria Center in the Jazan area. Malaria patients were grouped into three cohorts as follow: low (<500 parasites/µl of blood), moderate (500-1000 parasites/µl of blood), and high (>1000 parasites/µl of blood) parasitemia. The results show that the IL-27 variant rs181209 was significantly associated with malaria patients ( P  = 0.026). Similarly, the homozygous GG genotype of rs26528 was also associated with risk of developing P. falciparum malaria ( P  = 0.032). The minor allele C of variant rs181206 exhibited an association with low to moderate parasitemia ( P  = 0.046). Furthermore, the rs181209 AA genotype was statistically significant in age group 1-5 years ( P  = 0.049). In conclusion, this study suggests that variant rs181209 and rs26528 could be associated with the risk of malaria infection by P. falciparum in the population studied.
Databáze: MEDLINE
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