The evolution of intramitochondriality in Midichloria bacteria.

Autor: Floriano AM; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Pavia, Italy.; Université de Lyon, Université Lyon 1, CNRS, VetAgro Sup, Laboratoire de Biométrie et Biologie Evolutive, Villeurbanne, France., Batisti Biffignandi G; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Pavia, Italy.; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy., Castelli M; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Pavia, Italy., Olivieri E; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Pavia, Italy.; Pavia Department, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia-Romagna, Pavia, Italy., Clementi E; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Pavia, Italy., Comandatore F; Department of Biomedical and Clinical Sciences, Pediatric Clinical Research Center 'Romeo ed Enrica Invernizzi', University of Milan, Milan, Italy., Rinaldi L; Department of Veterinary Medicine and Animal Production, University of Naples Federico II, CREMOPAR Regione Campania, Naples, Italy., Opara M; Zoonotic Parasites Research Group, Department of Parasitology and Entomology, Faculty of Veterinary Medicine, University of Abuja, Abuja, Nigeria., Plantard O; INRAE, Oniris, BIOEPAR, Nantes, France., Palomar AM; Center of Rickettsiosis and Arthropod-Borne Diseases (CRETAV), San Pedro University Hospital, Center of Biomedical Research from La Rioja (CIBIR), Logroño, Spain., Noël V; MIVEGEC (Maladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle), University of Montpellier (UM), Montpellier, France., Vijay A; Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Lo N; School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia., Makepeace BL; Institute of Infection, Veterinary & Ecological Sciences, University of Liverpool, Liverpool, UK., Duron O; MIVEGEC (Maladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle), University of Montpellier (UM), Montpellier, France., Jex A; Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Melbourne, Victoria, Australia., Guy L; Department of Medical Biochemistry and Microbiology, Science for Life Laboratories, Uppsala University, Uppsala, Sweden., Sassera D; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Pavia, Italy.
Jazyk: angličtina
Zdroj: Environmental microbiology [Environ Microbiol] 2023 Nov; Vol. 25 (11), pp. 2102-2117. Date of Electronic Publication: 2023 Jun 12.
DOI: 10.1111/1462-2920.16446
Abstrakt: Midichloria spp. are intracellular bacterial symbionts of ticks. Representatives of this genus colonise mitochondria in the cells of their hosts. To shed light on this unique interaction we evaluated the presence of an intramitochondrial localization for three Midichloria in the respective tick host species and generated eight high-quality draft genomes and one closed genome, showing that this trait is non-monophyletic, either due to losses or multiple acquisitions. Comparative genomics supports the first hypothesis, as the genomes of non-mitochondrial symbionts are reduced subsets of those capable of colonising the organelles. We detect genomic signatures of mitochondrial tropism, including the differential presence of type IV secretion system and flagellum, which could allow the secretion of unique effectors and/or direct interaction with mitochondria. Other genes, including adhesion molecules, proteins involved in actin polymerisation, cell wall and outer membrane proteins, are only present in mitochondrial symbionts. The bacteria could use these to manipulate host structures, including mitochondrial membranes, to fuse with the organelles or manipulate the mitochondrial network.
(© 2023 Applied Microbiology International and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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