Longitudinal analysis of thoracic aortic expansion in non-syndromic real-world patients.
| Autor: | Ng J; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Ewe SH; Department of Cardiology, National Heart Centre Singapore, Singapore., Tan JL; Department of Cardiology, National Heart Centre Singapore, Singapore., Chao VT; Department of Cardiology, National Heart Centre Singapore, Singapore., Ding ZP; Department of Cardiology, National Heart Centre Singapore, Singapore., Ling LH; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Cardiology, National University Heart Centre Singapore, Singapore., Sin KY; Department of Cardiology, National Heart Centre Singapore, Singapore., Chua TS; Department of Cardiology, National Heart Centre Singapore, Singapore., Sahlén A; Department of Cardiology, National Heart Centre Singapore, Singapore.; Karolinska Institutet, Stockholm, Sweden. |
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| Jazyk: | angličtina |
| Zdroj: | Heliyon [Heliyon] 2023 Apr 25; Vol. 9 (5), pp. e15823. Date of Electronic Publication: 2023 Apr 25 (Print Publication: 2023). |
| DOI: | 10.1016/j.heliyon.2023.e15823 |
| Abstrakt: | Remodeling of the thoracic aorta is commonly seen and viewed as a precursor to an aortic aneurysm. However, while aneurysms have been shown to expand at a rate of approximately 1 mm annually, the expansion of the pre-aneurysmal aorta is poorly characterized, especially in relation to age, gender, and aortic size per se . We identified patients that had undergone echocardiography at least twice at a large university medical center. Diagnosis codes, medications, and blood test results were obtained from hospital records. Syndromic patients were excluded (e.g., Marfan's syndrome, bicuspid aortic valve). Final population comprised n = 24,928 patients (median age 61.2 years (inter-quartile range (IQR): 50.6-71.5); 55.8% males) that had undergone a median of 3 echocardiograms (2-4; range 2-27) during a median of 4.0 years (IQR: 2.3-6.2). Hypertension was present in 39.6% of patients and diabetes in 20.7%, median LV ejection fraction was 56.0% (IQR: 41.0-62.0). Aortic size measurements were analyzed in mixed models while clustering on individual patients. Mean expansion was determined for sinus of Valsalva as 1.93 (95% confidence interval; CI Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. (© 2023 The Authors.) |
| Databáze: | MEDLINE |
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