A case report and literature review of myocardial infarction with nonobstructive coronary arteries (MINOCA) possibly due to acute coronary vasospasm induced by misoprostol.

Autor:	Hau NV; Emergency Department, University Medical Center, Ho Chi Minh City, Vietnam., Han LTK; Emergency Department, University Medical Center, Ho Chi Minh City, Vietnam., Minh LHN; Emergency Department, University Medical Center, Ho Chi Minh City, Vietnam.; International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; AIBioMed Research Group, Taipei Medical University, Taipei, Taiwan.; Research Center for Artificial Intelligence in Medicine, Taipei Medical University, Taipei, Taiwan., Kiet NA; Emergency Department, University Medical Center, Ho Chi Minh City, Vietnam., Phong TT; Emergency Department, University Medical Center, Ho Chi Minh City, Vietnam., Duong NK; Emergency Department, University Medical Center, Ho Chi Minh City, Vietnam., Yen PTH; Emergency Department, University Medical Center, Ho Chi Minh City, Vietnam., Vinh NX; Emergency Department, University Medical Center, Ho Chi Minh City, Vietnam., Hao NQN; Pharmacy Department, University Medical Center, Ho Chi Minh City, Vietnam., Nguyen N; Department of Internal Medicine, Palmetto General Hospital, Hialeah, FL, United States., Truyen TTTT; Faculty of Medicine, Nam Can Tho University, Can Tho, Vietnam., Le NQK; AIBioMed Research Group, Taipei Medical University, Taipei, Taiwan.; Research Center for Artificial Intelligence in Medicine, Taipei Medical University, Taipei, Taiwan.; Professional Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Translational Imaging Research Center, Taipei Medical University Hospital, Taipei, Taiwan.
Jazyk:	angličtina
Zdroj:	Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2023 May 26; Vol. 10, pp. 1115358. Date of Electronic Publication: 2023 May 26 (Print Publication: 2023).
DOI:	10.3389/fcvm.2023.1115358
Abstrakt:	Coronary artery vasospasm (CVS), an uncommon cause of acute chest pain, can be provoked by vasoconstriction-induced medications. Misoprostol, a prostaglandin analog, is a safe medication to terminate a pregnancy. However, misoprostol can cause coronary artery vasospasm due to vasoconstrictor properties, leading to acute myocardial infarction with nonobstructive coronary arteries (MINOCA), especially in patients with a high risk for cardiovascular disease. We report a case of a 42-year-old female with a past medical history of hypertension who presented with ST-elevation myocardial infarction following the administration of a high-dose Misoprostol. The fact that coronary angiogram and intravascular ultrasound revealed normal coronary arteries suggested transient coronary vasospasm. CVS is a severe but rare cardiac adverse effect associated with high-dose misoprostol. This medication should be prescribed with caution and close monitoring, especially in those with pre-existing heart disease or cardiovascular risk factors. Our case raises awareness of severe cardiovascular complications that can be related to using misoprostol in high-risk patients. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2023 Hau, Han, Minh, Kiet, Phong, Duong, Yen, Vinh, Hao, Nguyen, Truyen and Le.)
Databáze:	MEDLINE
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