Peritoneal regression grading score (PRGS): first evidence for independent predictive and prognostic significance.

Autor:	Baake J; National Center for Pleura and Peritoneum, Comprehensive Cancer Center South-Western Germany, Tübingen-Stuttgart, Germany.; Department of General and Transplant Surgery, Eberhard-Karls-University Tübingen, Tübingen, Germany., Nadiradze G; National Center for Pleura and Peritoneum, Comprehensive Cancer Center South-Western Germany, Tübingen-Stuttgart, Germany.; Department of General and Transplant Surgery, Eberhard-Karls-University Tübingen, Tübingen, Germany., Archid R; National Center for Pleura and Peritoneum, Comprehensive Cancer Center South-Western Germany, Tübingen-Stuttgart, Germany.; Department of General and Transplant Surgery, Eberhard-Karls-University Tübingen, Tübingen, Germany., Königsrainer A; National Center for Pleura and Peritoneum, Comprehensive Cancer Center South-Western Germany, Tübingen-Stuttgart, Germany.; Department of General and Transplant Surgery, Eberhard-Karls-University Tübingen, Tübingen, Germany., Bösmüller H; National Center for Pleura and Peritoneum, Comprehensive Cancer Center South-Western Germany, Tübingen-Stuttgart, Germany.; Institute of Pathology, Eberhard-Karls-University Tübingen, Tübingen, Germany., Reymond M; National Center for Pleura and Peritoneum, Comprehensive Cancer Center South-Western Germany, Tübingen-Stuttgart, Germany.; Department of General and Transplant Surgery, Eberhard-Karls-University Tübingen, Tübingen, Germany., Solass W; National Center for Pleura and Peritoneum, Comprehensive Cancer Center South-Western Germany, Tübingen-Stuttgart, Germany.; Institute of Pathology, Eberhard-Karls-University Tübingen, Tübingen, Germany.; Institute of Tissue Medicine and Pathology, University Bern, Bern, Switzerland.
Jazyk:	angličtina
Zdroj:	Pleura and peritoneum [Pleura Peritoneum] 2023 May 18; Vol. 8 (2), pp. 55-63. Date of Electronic Publication: 2023 May 18 (Print Publication: 2023).
DOI:	10.1515/pp-2023-0014
Abstrakt:	Objectives: The peritoneal regression grading score (PRGS) is a four-tied pathologic score measuring tumor regression in biopsies from patients with peritoneal metastasis (PM) receiving chemotherapy. Methods: This retrospective analysis of a prospective registry (NCT03210298) analyses 97 patients with isolated PM under palliative chemotherapy. We examined the predictive value of the initial PRGS for overall survival (OS) and the prognostic value of PRGS in repeated peritoneal biopsies. Results: The 36 (37.1 %) patients with an initial mean PRGS≤2 had a longer median OS (12.1 months, CI 95 % 7.8-16.4) vs. 8.0 months (CI 95 % 5.1-10.8 months) in 61 (62.9 %) patients with PRGS≥3 (p=0.02) After stratification, the initial PRGS was an independent predictor of OS (Cox-regression, p<0.05). Out of 62 patients receiving≥two chemotherapy cycles, 42 (67.7 %) had a histological response (defined as a lower or stable mean PRGS in successive therapy cycles), and 20 (32.3 %) progressed (defined as an increasing mean PRGS). PRGS response was associated with a longer median OS (14.6 months, CI 5-95 % 6.0-23.2) vs. 6.9 (CI 5-95 % 0.0-15.9) months. PRGS response was prognostic in the univariate analysis (p=0.017). Thus, PRGS had both a predictive and prognostic significance in patients with isolated PM receiving palliative chemotherapy in this patient cohort. Conclusions: This is the first evidence for the independent predictive and prognostic significance of PRGS in PM. These encouraging results need validation in an adequately powered, prospective study. Competing Interests: Competing interests: The authors state no conflict of interest. (© 2023 the author(s), published by De Gruyter, Berlin/Boston.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu