Pharmacist-Led Interventions to Reduce Drug-Related Problems in Prescribing for Pediatric Outpatients in a Developing Country: A Randomized Controlled Trial.

Autor:	Nguyen PM; Faculty of Medicine (PMN, TKN, HHVL), Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam., Nguyen KT; Faculty of Medicine (PMN, TKN, HHVL), Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam.; Department of Pharmacology and Clinical Pharmacy (STP, TTCL, HGD, TN), Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam.; Faculty of Pharmacy (KT), University of Groningen, Groningen, the Netherlands., Pham ST; Department of Pharmacology and Clinical Pharmacy (STP, TTCL, HGD, TN), Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam., Thanh Le VT; Department of Pharmacy (VTTL), Can Tho Children's Hospital, Can Tho, Vietnam., Thi Le TC; Department of Pharmacology and Clinical Pharmacy (STP, TTCL, HGD, TN), Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam., Diep HG; Department of Pharmacology and Clinical Pharmacy (STP, TTCL, HGD, TN), Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam., Minh Le NN; Department of Traditional Medicine (NMNL), Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam., Vinh Ly HH; Faculty of Medicine (PMN, TKN, HHVL), Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam., Nhu Nguyen TT; Office of Sciences and Technology - External Relations (TTNN), Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam., Lam AN; Faculty of Public Health (ANL), Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam., Nguyen TH; Department of Clinical Pharmacy (THN), University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam., Nguyen T; Department of Pharmacology and Clinical Pharmacy (STP, TTCL, HGD, TN), Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam.
Jazyk:	angličtina
Zdroj:	The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG [J Pediatr Pharmacol Ther] 2023; Vol. 28 (3), pp. 212-221. Date of Electronic Publication: 2023 Jun 02.
DOI:	10.5863/1551-6776-28.3.212
Abstrakt:	Objective: To evaluate a pharmacist-led intervention's effectiveness in reducing drug-related problems (DRPs ( related to prescriptions for pediatric outpatients. Methods: We conducted a randomized controlled trial. We recruited and randomly assigned 31 physicians to control or intervention groups. We collected 775 prescriptions (375 from the control group and 400 from the intervention group) at the start. For 3 weeks, intervention physicians received additional information and meetings with pharmacists in addition to the usual practices of the hospital. We then collected prescriptions at the end of the study. We classified DRPs, based on reliable references (Supplemental Table S1) at baseline and endpoint (a week after the intervention). The primary outcome was the proportion of prescriptions with DRPs, and secondary outcomes were the proportions of prescriptions with specific DRP types. Results: The influence of the intervention on general DRPs and specific DRPs was the study's main finding. The pharmacist-led intervention helped reduce the prescriptions with DRPs proportion in the intervention group to 41.0%, compared with 49.3% in the control group (p < 0.05). The DRPs proportion related to the timing of administration relative to meals, unlike the other DRP types, increased in the control group (from 31.7% to 34.9%) and decreased in the intervention group (from 31.3% to 25.3%), with a significant difference between the 2 groups at endpoint (p < 0.01). Patients aged >2 to ≤6 years (OR, 1.871; 95% CI, 1.340-2.613) and receiving ≥5 drugs (OR, 5.037; 95% CI, 2.472-10.261) were at greater risk of experiencing DRPs related to prescribing. Conclusions: A pharmacist-led intervention improved DRP occurrence related to physicians' prescribing. Pharmacists could be involved in in-depth research with physicians in the prescribing process to provide tailored interventions. Competing Interests: Disclosures. The author declares that there is no relevant or material financial interests that relate to the research described in this paper. (Copyright. Pediatric Pharmacy Association. All rights reserved. For permissions, email: membership@pediatricpharmacy.org 2023.)
Databáze:	MEDLINE
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