Disposition of a single oral dose of a cannabidiol medication in healthy cats.
| Autor: | Jukier T; Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, United States., Cruz-Espindola C; Clinical Pharmacology Laboratory, Department of Anatomy and Physiology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States., Martin D; Scott Ritchey Research Center, Department of Anatomy and Physiology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States., Boothe DM; Clinical Pharmacology Laboratory, Department of Anatomy and Physiology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Frontiers in veterinary science [Front Vet Sci] 2023 May 26; Vol. 10, pp. 1181517. Date of Electronic Publication: 2023 May 26 (Print Publication: 2023). |
| DOI: | 10.3389/fvets.2023.1181517 |
| Abstrakt: | The historical use of the marijuana plant for medicinal purposes is long. One of the historical uses has been for the treatment of epilepsy. Recently, the Food and Drug Administration has approved a highly purified cannabidiol medication for the add on therapy in people with certain forms of epilepsy. With the increase interest of the use of cannabidiol in the veterinary community, the aim of this study was to describe the disposition of a single dose of a cannabidiol medication in healthy cats in both the fed and fasted state. Pharmacokinetic analysis reveals that relative bioavailability of cannabidiol shows a near eleven-fold increase when administered in the fed state compared to the fasted state. Additionally, concentrations achieved at a dose of 5 mg/kg, may be sufficient to explore the therapeutic potential in cats with epilepsy. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Jukier, Cruz-Espindola, Martin and Boothe.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|