Physiological and Neurobehavioral Disturbances Induced by Al 2 O 3 Nanoparticle Intoxication in Nile Tilapia Fish: Benefits of Dietary Chamomile Essential Oil.

Autor: Farag MR; Forensic Medicine and Toxicology Department, Veterinary Medicine Faculty, Zagazig University, Zagazig 44519, Egypt., Zheng C; Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Key Laboratory of Animal Nutrition and Feed Science (South China) of Ministry of Agriculture, State Key Laboratory of Livestock and Poultry Breeding, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong Key Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China., Gharib HSA; Behaviour and Management of Animal, Poultry and Aquatics Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt., El-Hady E; Anatomy and Embryology Department Veterinary Medicine Faculty, Zagazig University, Zagazig 44519, Egypt., Mahdy EAA; Anatomy and Embryology Department Veterinary Medicine Faculty, Zagazig University, Zagazig 44519, Egypt., Abo-Elmaaty AMA; Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt., Abou-Zeid SM; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, University of Sadat City, Sadat City 6012201, Egypt., Alagawany M; Poultry Department, Faculty of Agriculture, Zagazig University, Zagazig 44519, Egypt., Di Cerbo A; School of Biosciences and Veterinary Medicine, University of Camerino, Matelica, Italy., Azzam MM; Department of Animal Production College of Food & Agriculture Sciences, King Saud University, Riyadh 11451, Saudi Arabia., Al-Abdullatif AA; Department of Animal Production College of Food & Agriculture Sciences, King Saud University, Riyadh 11451, Saudi Arabia., Hassan MA; Forensic Medicine and Toxicology Department, Veterinary Medicine Faculty, Zagazig University, Zagazig 44519, Egypt.
Jazyk: angličtina
Zdroj: Aquaculture nutrition [Aquac Nutr] 2023 Jun 03; Vol. 2023, pp. 6700708. Date of Electronic Publication: 2023 Jun 03 (Print Publication: 2023).
DOI: 10.1155/2023/6700708
Abstrakt: Despite the usage of nanoparticles (NPs) is rapidly increasing, several experts have noted the risk of their release into ecosystems and their potential negative impacts on biological systems. However, the available studies on the neurobehavioral impacts of aluminum oxide nanoparticles (Al 2 O 3 NPs) on aquatic organisms are little. Hence, this study targeted to ascertain the harmful effects of Al 2 O 3 NPs on behavioral characteristics and genotoxic and oxidative damages in Nile tilapia fish. In addition, the beneficial role of chamomile essential oil (CEO) supplementation in reducing these effects was also investigated. In the current study, fish were distributed into 4 equal groups ( n = 60 fish per group). The control group was fed a plain diet only, the CEO group received a basic diet complemented with CEO at a level of 2 mg/kg diet, the ALNP group received a basic diet and was exposed to an approximate concentration of 1/10th LC 50 of ALNPs nearly 5.08 mg/L, and the combination group (ALNPs/CEO group) received a basal diet coadministered with ALNPs and CEO at the aforementioned percentages. The findings revealed that O. niloticus exhibit neurobehavioral changes along with changes in the level of GABA, monoamines in the brain tissue, and serum amino acid neurotransmitters, besides a reduction of AChE and Na + /K + -ATPase activities. In addition to brain tissue oxidative damage with upregulation of proinflammatory and stress genes, such as HSP70 and caspase-3, supplementation of CEO significantly reduced the negative impacts of ALNPs. These results showed that CEO has neuroprotective, antioxidant, genoprotective, anti-inflammatory, and antiapoptotic properties in fish that have been exposed to ALNPs. Therefore, we advise its usage as a valuable addition to fish diet.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2023 Mayada R. Farag et al.)
Databáze: MEDLINE
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