Visuo-vestibular and cognitive connections of the vestibular neuromatrix are conserved across age and injury populations.

Autor: Smith JL; Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA., Diekfuss JA; Emory Sports Performance and Research Center (SPARC), Flowery Branch, Georgia, USA.; Emory Sports Medicine Center, Atlanta, Georgia, USA.; Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA., Dudley JA; Pediatric Neuroimaging Research Consortium, Division of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Ahluwalia V; Georgia State University/Georgia Tech Center for Advanced Brain Imaging (CABI), Atlanta, Georgia, USA., Zuleger TM; Emory Sports Performance and Research Center (SPARC), Flowery Branch, Georgia, USA.; Emory Sports Medicine Center, Atlanta, Georgia, USA.; Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA.; Neuroscience Graduate Program, University of Cincinnati, Cincinnati, Ohio, USA., Slutsky-Ganesh AB; Emory Sports Performance and Research Center (SPARC), Flowery Branch, Georgia, USA.; Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA., Yuan W; Pediatric Neuroimaging Research Consortium, Division of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Foss KDB; Emory Sports Performance and Research Center (SPARC), Flowery Branch, Georgia, USA., Gore RK; Mild TBI Brain Health and Recovery Lab, Shepherd Center, Atlanta, Georgia, USA.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA., Myer GD; Emory Sports Performance and Research Center (SPARC), Flowery Branch, Georgia, USA.; Emory Sports Medicine Center, Atlanta, Georgia, USA.; Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA.; Youth Physical Development Centre, Cardiff Metropolitan University, Wales, UK., Allen JW; Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.; Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.
Jazyk: angličtina
Zdroj: Journal of neuroimaging : official journal of the American Society of Neuroimaging [J Neuroimaging] 2023 Nov-Dec; Vol. 33 (6), pp. 1003-1014. Date of Electronic Publication: 2023 Jun 11.
DOI: 10.1111/jon.13136
Abstrakt: Background and Purpose: Given the prevalence of vestibular dysfunction in pediatric concussion, there is a need to better understand pathophysiological disruptions within vestibular and associated cognitive, affective, and sensory-integrative networks. Although current research leverages established intrinsic connectivity networks, these are nonspecific for vestibular function, suggesting that a pathologically guided approach is warranted. The purpose of this study was to evaluate the generalizability of the previously identified "vestibular neuromatrix" in adults with and without postconcussive vestibular dysfunction to young athletes aged 14-17.
Methods: This retrospective study leveraged resting-state functional MRI data from two sites. Site A included adults with diagnosed postconcussive vestibular impairment and healthy adult controls and Site B consisted of young athletes with preseason, postconcussion, and postseason time points (prospective longitudinal data). Adjacency matrices were generated from preprocessed resting-state data from each sample and assessed for overlap and network structure in MATLAB.
Results: Analyses indicated the presence of a conserved "core" network of vestibular regions as well as areas subserving visual, spatial, and attentional processing. Other vestibular connections were also conserved across samples but were not linked to the "core" subnetwork by regions of interest included in this study.
Conclusions: Our results suggest that connections between central vestibular, visuospatial, and known intrinsic connectivity networks are conserved across adult and pediatric participants with and without concussion, evincing the significance of this expanded, vestibular-associated network. Our findings thus support this network as a workable model for investigation in future studies of dysfunction in young athlete populations.
(© 2023 American Society of Neuroimaging.)
Databáze: MEDLINE
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