Prevalence of nonalcoholic fatty liver disease in a Spanish town: a population-based study.

Autor: Cusacovich I; Department of Internal Medicine, Hospital Clínico Universitario de Valladolid, Spain. Electronic address: icusac@hotmail.com., Sánchez-Lite I; Department of Radiology, Hospital Clínico Universitario de Valladolid, Spain., Toribio B; Department of Radiology, Hospital Clínico Universitario de Valladolid, Spain., González JM; Department of Gastroenterology and Hepatology, Hospital Clínico Universitario de Valladolid, Spain; Centre Hospitalier Monkole, Kinshasa, Democratic Republic of Congo., Pérez-Rubio A; Department of Epidemiology, Hospital Clínico Universitario de Valladolid, Spain., Andaluz-Ojeda D; Intensive Care Unit, Hospital Clínico Universitario de Valladolid, Spain.
Jazyk: angličtina
Zdroj: Revista clinica espanola [Rev Clin Esp (Barc)] 2023 Aug-Sep; Vol. 223 (7), pp. 396-404. Date of Electronic Publication: 2023 Jun 09.
DOI: 10.1016/j.rceng.2023.04.012
Abstrakt: Objective: Nonalcoholic fatty liver disease (NAFLD) is western countries' most important cause of hepatic steatosis and hypertransaminasemia. The objective was to evaluate the prevalence of NAFLD among 261,025 people in the East Valladolid public healthcare area in Spain.
Methods: We randomly selected 1800 participants from a public healthcare system card database, representing most of the population. We performed a medical record, measurement of anthropometric parameters, abdominal ultrasound, and blood tests to rule out hepatic disease in all patients. We calculated the FLI score in all patients.
Results: 448 participants agreed to participate in the study. The prevalence of nonalcoholic fatty liver disease in our study was 22.3% [18.5%-26.2%]. Prevalence was highest between 50 and 70 years, increasing with age (p < 0.006). There were no significant differences in sex (p = 0.338). The median Body mass index was 27.2, and NAFLD was related to the weight (p < 0,001) and abdominal perimeter (p < 0.001). Logistic regression analysis showed GGT lower than 26 UI/ml, body mass index higher than 31, and HOMA IR greater than 2.54 as independent factors to predict NAFLD in the sample. NAFLD diagnosis matched with an elevated FLI score in 88% of cases.
Conclusion: According to other epidemiological studies, NAFLD's prevalence is very high. A complete study with a clinical consultation, image studies, and blood tests in all patients allows us to assess the prevalence of NAFLD in the population.
(Copyright © 2023 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.)
Databáze: MEDLINE
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