| Autor: |
Tschiderer L; Institute of Health Economics Medical University of Innsbruck Innsbruck Austria., Seekircher L; Institute of Health Economics Medical University of Innsbruck Innsbruck Austria., Izzo R; Department of Advanced Biomedical Sciences Federico II University Naples Italy., Mancusi C; Department of Advanced Biomedical Sciences Federico II University Naples Italy., Manzi MV; Department of Advanced Biomedical Sciences Federico II University Naples Italy., Baldassarre D; Department of Medical Biotechnology and Translational Medicine University of Milan Milan Italy.; Centro Cardiologico Monzino Stituto di Ricovero e Cura a Carattere Scientifico Milan Italy., Amato M; Centro Cardiologico Monzino Stituto di Ricovero e Cura a Carattere Scientifico Milan Italy., Tremoli E; Maria Cecilia Hospital Cotignola (Ravenna) Italy., Veglia F; Maria Cecilia Hospital Cotignola (Ravenna) Italy., Tuomainen TP; Institute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio Finland., Kauhanen J; Institute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio Finland., Voutilainen A; Institute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio Finland., Iglseder B; Department of Geriatric Medicine Gemeinnützige Salzburger Landeskliniken Betriebsgesellschaft GmbH Christian-Doppler-Klinik Salzburg Austria.; Department of Geriatric Medicine Paracelsus Medical University Salzburg Austria., Lind L; Department of Medicine Uppsala University Uppsala Sweden., Rundek T; Department of Neurology University of Miami Miller School of Medicine Miami FL., Desvarieux M; Department of Epidemiology, Mailman School of Public Health Columbia University New York NY.; METHODS Core, Centre de Recherche Epidémiologie et Statistique Paris Sorbonne Cité Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 1153 Paris France., Kato A; Blood Purification Unit Hamamatsu University Hospital Hamamatsu Japan., de Groot E; Imagelabonline and Cardiovascular Erichem the Netherlands.; Department of Gastroenterology and Hepatology, Amsterdam University Medical Center-Academic Medical Centre Amsterdam the Netherlands., Aşçi G; Nephrology Department Ege University School of Medicine Bornova-Izmir Turkey., Ok E; Nephrology Department Ege University School of Medicine Bornova-Izmir Turkey., Agewall S; Department of Clinical Sciences, Danderyd Hospital Division of Cardiology Karolinska Institutet Stockholm Sweden.; Institute of Clinical Sciences University of Oslo Oslo Norway., Beulens JWJ; Department of Epidemiology and Data Science, Amsterdam University Medical Center-Location Vrije Universiteit Medical Center Amsterdam the Netherlands., Byrne CD; School of Human Development and Health, Faculty of Medicine University of Southampton Southampton UK.; Southampton National Institute for Health and Care Research, Biomedical Research Centre University Hospital Southampton Southampton UK., Calder PC; School of Human Development and Health, Faculty of Medicine University of Southampton Southampton UK.; Southampton National Institute for Health and Care Research, Biomedical Research Centre University Hospital Southampton Southampton UK., Gerstein HC; Department of Medicine and Population Health Research Institute McMaster University Hamilton Ontario Canada.; Hamilton General Hospital Hamilton Ontario Canada., Gresele P; Division of Internal and Cardiovascular Medicine, Department of Medicine and Surgery University of Perugia Perugia Italy., Klingenschmid G; Department of Neurology Medical University of Innsbruck Innsbruck Austria., Nagai M; Department of Internal Medicine General Medicine and Cardiology, Hiroshima City Asa Hospital Hiroshima Japan., Olsen MH; Department of Internal Medicine, Holbaek Hospital University of Southern Denmark Odense Denmark., Parraga G; Department of Medical Biophysics, Robarts Research Institute Western University London ON Canada., Safarova MS; Department of Cardiovascular Medicine University of Kansas Medical Center Kansas City KS., Sattar N; British Heart Foundation Glasgow Cardiovascular Research Centre University of Glasgow Glasgow UK., Skilton M; Charles Perkins Centre, Faculty of Medicine and Health University of Sydney Sydney NSW Australia., Stehouwer CDA; Department of Internal Medicine and Cardiovascular Research Institute Maastricht Maastricht University Medical Centre Maastricht the Netherlands., Uthoff H; Department of Angiology University Hospital Basel Basel Switzerland., van Agtmael MA; Department of Internal Medicine Amsterdam University Medical Center, Vrije Universiteit Amsterdam the Netherlands., van der Heijden AA; Department of General Practice, Amsterdam University Medical Center-Location Vrije Universiteit Medical Center Amsterdam the Netherlands., Zozulińska-Ziółkiewicz DA; Department of Internal Medicine and Diabetology Poznan University of Medical Sciences Poznan Poland., Park HW; Division of Cardiology, Department of Internal Medicine Chungnam National University Sejong Hospital Sejong-si South Korea., Lee MS; Department of Preventive Medicine, College of Medicine Konyang University Daejeon South Korea.; Department of Occupational and Environmental Medicine Konyang University Hospital Daejeon South Korea., Bae JH; Heart Center, Konyang University Hospital Daejeon South Korea.; Department of Cardiology Konyang University College of Medicine Daejeon South Korea., Beloqui O; Department of Internal Medicine University Clinic of Navarra Navarra Spain., Landecho MF; Department of Internal Medicine University Clinic of Navarra Navarra Spain., Plichart M; Paris Cardiovascular Research Centre University Paris Descartes Paris France.; Fondation Santé Service, Hospital at Home Levallois-Perret France., Ducimetiere P; Faculty of Medicine University Paris Descartes Paris France., Empana JP; Paris Cardiovascular Research Centre University Paris Descartes Paris France., Bokemark L; Wallenberg Laboratory for Cardiovascular Research University of Gothenburg Gothenburg Sweden., Bergström G; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.; Department of Clinical Physiology Sahlgrenska University Hospital, Region Västragötaland Gothenburg Sweden., Schmidt C; Wallenberg Laboratory for Cardiovascular Research University of Gothenburg Gothenburg Sweden., Castelnuovo S; Centro Dislipidemie, Aziende Socio Sanitarie Territoriali Grande Ospedale Metropolitano Niguarda Milan Italy., Calabresi L; Department of Pharmacological and Biomolecular Sciences University of Milan Milan Italy., Norata GD; Department of Pharmacological and Biomolecular Sciences University of Milan Milan Italy.; Società Italiana per lo Studio dell'Aterosclerosi Center for the Study of Atherosclerosis, Bassini Hospital Cinisello Balsamo Italy., Grigore L; Stituto di Ricovero e Cura a Carattere Scientifico Multimedica Milan Italy., Catapano A; Department of Pharmacological and Biomolecular Sciences University of Milan Milan Italy.; Stituto di Ricovero e Cura a Carattere Scientifico Multimedica Milan Italy., Zhao D; Department of Epidemiology, Beijing Anzhen Hospital Capital Medical University Beijing China., Wang M; Department of Epidemiology, Beijing Anzhen Hospital Capital Medical University Beijing China., Liu J; Department of Epidemiology, Beijing Anzhen Hospital Capital Medical University Beijing China., Ikram MA; Department of Epidemiology Erasmus University Medical Center Rotterdam the Netherlands., Kavousi M; Department of Epidemiology Erasmus University Medical Center Rotterdam the Netherlands., Bots ML; Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht the Netherlands., Sweeting MJ; Department of Health Sciences University of Leicester Leicester UK.; Department of Public Health and Primary Care University of Cambridge Cambridge UK., Lorenz MW; Klinik für Neurologie Krankenhaus Nordwest Frankfurt am Main Germany.; Department of Neurology Goethe University Frankfurt am Main Germany., Willeit P; Institute of Health Economics Medical University of Innsbruck Innsbruck Austria.; Department of Public Health and Primary Care University of Cambridge Cambridge UK. |
| Abstrakt: |
Background The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development. Methods and Results We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I 2 =63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I 2 =59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I 2 =57.1%; 14 studies; 17 352 participants; 6991 incident plaques). Conclusions Our large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent of traditional cardiovascular risk factors. |
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