Agaricus blazei Murill polysaccharides/alginate/poly(vinyl alcohol) blend as dressings for wound healing.

Autor: Saraiva MM; Polymer and Material Innovation Laboratory, Department of Organic and Inorganic Chemistry, Federal University of Ceará, Pici Campus, CEP 60455-760 Fortaleza, CE, Brazil., Campelo MDS; Polymer and Material Innovation Laboratory, Department of Organic and Inorganic Chemistry, Federal University of Ceará, Pici Campus, CEP 60455-760 Fortaleza, CE, Brazil; Department of Pharmacy, Federal University of Ceará, Porangabussu Campus, CEP 60430-370, Fortaleza, CE, Brazil., Câmara Neto JF; Polymer and Material Innovation Laboratory, Department of Organic and Inorganic Chemistry, Federal University of Ceará, Pici Campus, CEP 60455-760 Fortaleza, CE, Brazil., Gonzaga MLDC; Polymer and Material Innovation Laboratory, Department of Organic and Inorganic Chemistry, Federal University of Ceará, Pici Campus, CEP 60455-760 Fortaleza, CE, Brazil; Food Packaging Technology Laboratory, Embrapa Agroindústria Tropical, Pici, CEP 60511-110 Fortaleza, CE, Brazil., Bastos MDSR; Food Packaging Technology Laboratory, Embrapa Agroindústria Tropical, Pici, CEP 60511-110 Fortaleza, CE, Brazil., Soares SA; Polymer and Material Innovation Laboratory, Department of Organic and Inorganic Chemistry, Federal University of Ceará, Pici Campus, CEP 60455-760 Fortaleza, CE, Brazil., Ricardo NMPS; Polymer and Material Innovation Laboratory, Department of Organic and Inorganic Chemistry, Federal University of Ceará, Pici Campus, CEP 60455-760 Fortaleza, CE, Brazil., Cerqueira GS; Image Processing and Microscopy Studies Center, Department of Morphology, Federal University of Ceará, Porangabussu Campus, CEP 60416-030 Fortaleza, CE, Brazil., Leitão RFC; Image Processing and Microscopy Studies Center, Department of Morphology, Federal University of Ceará, Porangabussu Campus, CEP 60416-030 Fortaleza, CE, Brazil., Ribeiro MENP; Polymer and Material Innovation Laboratory, Department of Organic and Inorganic Chemistry, Federal University of Ceará, Pici Campus, CEP 60455-760 Fortaleza, CE, Brazil; Department of Pharmacy, Federal University of Ceará, Porangabussu Campus, CEP 60430-370, Fortaleza, CE, Brazil. Electronic address: elenir.ribeiro@ufc.br.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2023 Jul 31; Vol. 244, pp. 125278. Date of Electronic Publication: 2023 Jun 08.
DOI: 10.1016/j.ijbiomac.2023.125278
Abstrakt: Macromolecules with antioxidant properties such as polysaccharides from Agaricus blazei Murill mushroom (PAbs) are an excellent option for manufacturing wound dressings. Based on this, this study aimed to analyze preparation, physicochemical characterization, and assessment of the potential wound-healing activity of films based on sodium alginate and polyvinyl alcohol loaded with PAbs. PAbs did not significantly alter the cell viability of human neutrophils in a concentration range of 1-100 μg mL -1 . The Infrared Spectroscopy (FTIR) indicates that the components present in the films (PAbs/Sodium Alginate (SA)/Polyvinyl Alcohol (PVA)) present an increase in hydrogen bonds due to the increase of hydroxyls present in the components. Thermogravimetry (TGA), Differential Scanning Calorimetry (DSC) and X-ray Diffraction (XRD) characterizations indicate a good miscibility between the components where PAbs increasing the amorphous characteristics of the films and that the addition of SA increased the mobility of the chains PVA polymers. The addition of PAbs to films significantly improves properties such as mechanical, thickness, and water vapor permeation. The morphological study evidenced good miscibility between the polymers. The wound healing evaluation indicated that F100 film presented better results from the fourth day onward compared to the other groups. It favored the formation of a thicker dermis (476.8 ± 18.99 μm), with greater collagen deposition and a significant reduction in malondialdehyde and nitrite/nitrate, markers of oxidative stress. These results indicate that PAbs is a candidate for wound dressing.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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