Striatal dopamine in anhedonia: A simultaneous [ 11 C]raclopride positron emission tomography and functional magnetic resonance imaging investigation.

Autor: Phillips RD; Department of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC, United States. Electronic address: Rachel.phillips@unc.edu., Walsh EC; Department of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, NC, United States., Zürcher NR; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States., Lalush DS; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, United States., Kinard JL; Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, Chapel Hill, NC, United States., Tseng CE; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States., Cernasov PM; Department of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC, United States., Kan D; Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, Chapel Hill, NC, United States., Cummings K; Department of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC, United States., Kelley L; Department of Psychiatry & Behavioral Sciences, Duke University, Durham, NC, United States., Campbell D; Department of Psychiatry & Behavioral Sciences, Duke University, Durham, NC, United States., Dillon DG; Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, United States., Pizzagalli DA; Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, United States., Izquierdo-Garcia D; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States., Hooker JM; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States., Smoski MJ; Department of Psychiatry & Behavioral Sciences, Duke University, Durham, NC, United States., Dichter GS; Department of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC, United States; Department of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, NC, United States; Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, Chapel Hill, NC, United States.
Jazyk: angličtina
Zdroj: Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2023 Aug; Vol. 333, pp. 111660. Date of Electronic Publication: 2023 Jun 01.
DOI: 10.1016/j.pscychresns.2023.111660
Abstrakt: Background: Anhedonia is hypothesized to be associated with blunted mesocorticolimbic dopamine (DA) functioning in samples with major depressive disorder. The purpose of this study was to examine linkages between striatal DA, reward circuitry functioning, anhedonia, and, in an exploratory fashion, self-reported stress, in a transdiagnostic anhedonic sample.
Methods: Participants with (n = 25) and without (n = 12) clinically impairing anhedonia completed a reward-processing task during simultaneous positron emission tomography and magnetic resonance (PET-MR) imaging with [ 11 C]raclopride, a DA D2/D3 receptor antagonist that selectively binds to striatal DA receptors.
Results: Relative to controls, the anhedonia group exhibited decreased task-related DA release in the left putamen, caudate, and nucleus accumbens and right putamen and pallidum. There were no group differences in task-related brain activation (fMRI) during reward processing after correcting for multiple comparisons. General functional connectivity (GFC) findings revealed blunted fMRI connectivity between PET-derived striatal seeds and target regions in the anhedonia group. Associations were identified between anhedonia severity and the magnitude of task-related DA release to rewards in the left putamen, but not mesocorticolimbic GFC.
Conclusions: Results provide evidence for reduced striatal DA functioning during reward processing and blunted mesocorticolimbic network functional connectivity in a transdiagnostic sample with clinically significant anhedonia.
Competing Interests: Declaration of Competing Interest Over the past 3 years, Dr. Pizzagalli has received consulting fees from Albright Stonebridge Group, Boehringer Ingelheim, Compass Pathways, Engrail Therapeutics, Neumora Therapeutics (formerly BlackThorn Therapeutics), Neurocrine Biosciences, Neuroscience Software, Otsuka, Sunovion, and Takeda; he has received honoraria from the Psychonomic Society (for editorial work) and from Alkermes; he has received research funding from the Brain and Behavior Research Foundation, the Dana Foundation, Millennium Pharmaceuticals, and NIMH; he has received stock options from Compass Pathways, Engrail Therapeutics, Neumora Therapeutics, and Neuroscience Software. No funding from these entities was used to support the current work, and all views expressed are solely those of the authors. The other authors have no conflicts of interest or relevant disclosures.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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